Objective
The aim of the present project is the systematic development of peptide-based low molecular mass functional model complexes of metalloenzymes, possessing either hydrolytic or redox activity.
Such compounds, being smaller, more robust and better available than the enzymes themselves, are useful to accelerate chemical reactions under mild conditions and are of great interest for biotechnological, medicinal and industrial applications, both from economical and environmental point of view.
Within the scope of both sub-projects (functional model complexes of hydrolytic and redox enzymes) the synthesis of two types of ligands is envisaged:
- histidine-rich linear peptides, or
- tripode-like branched peptides assembling three histidine residues.
These structures are expected to imitate protein folding, which would allow multiimidazole binding in the physiological pH-range (i.e. the retardation of amide co-ordination). In case of promising candidates, the synthesis of PNA-peptide hybrids will be undertaken to induce strong and site selective DNA/RNA binding.
After completing the equilibrium and solution structural (UV-VIS, CD, EPR, NMR) studies of the Cu(II)- and Zn(II)-ligand systems, sufficient information are in hand to plan the optimal conditions (pH, concentrations, metal-to-ligand ratios, etc.) for the kinetic measurements, targeting both the hydrolysis of DNA/RNA models (Cu(II) and Zn(II) complexes) and the oxidation of various aromatic compounds (Cu(II) complexes). The present proposal aims to reintegrate a talented young scientist in his country of origin.
The financial aid of the Marie Curie European Reintegration Grant, especially the purchase of an HPLC instrument, will fundamentally facilitate the build up of the candidate's own small group comprising o f postgraduate students. The scientific network, established during the current mobility grant of the applicant, would further improve the trans-national collaborations of the host institute.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins protein folding
- natural sciences chemical sciences organic chemistry aromatic compounds
- natural sciences biological sciences genetics RNA
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-11
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
SZEGED
Hungary
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.