Objective
Endothelium is a dynamic orhan with secretory and immunological functions that plays a key role in homeostasis, thrombosis and inflammation. Endothelial cells create a continuous monolayer lining blood vessels, semi-permeable to macromolecules, salutes and liquid, highly regulated by blood-born mediators.
The endothelial barrier function is critically dependent on the integrity of cell-cell adhesion structures, especially the tight junctions and the adherens junctions (AJ). Endothelial AJ associates with acti n cytoskeleton and link neighbouring cells through the transmembrane VE-cadherin (Vascular Endothelial cadherin), the molecule that constitutes the backbone of AJ. Studies have shown that disassembly of AJ is an essential feature of the increased endothelial permeability response.
Endothelial AJ are dynamic structures which respond to inflammatory mediators and thus modify their adhesion strength and alter endothelial barrier function. Cell-cell adhesion strength is regulated by: a) the extracellular cadherin repeats domain, and b) the cadherin cytoplasmic domain where p120- and b-catenins bind.
These molecules function as essential linkers between cadherin and the actin cytoskeleton, which is requirement for strong cell-cell adhesion. Proinflammatory mediators such as thrombin, histamine and bradykinin activate their endothelial surface receptors and induce increased endothelial permeability responses through second messengers activation. In such cases endothelial cell-cell adhesion mediated by AJ is modulate d from strong to weak.
The proposed studies aim to explore mechanisms responsible for reversal of the permeability increase and barrier recovery. We will study how endothelial adhesive structures and the associated cytoskeleton regulate barrier function. Specifically how adherens junctions participate in the reformation of endothelial junctions after the administration of pro-inflammatory agents.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine angiology vascular diseases
- natural sciences mathematics pure mathematics topology
- medical and health sciences clinical medicine cardiology cardiovascular diseases arteriosclerosis
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine physiology homeostasis
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-12
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IRG - Marie Curie actions-International re-integration grants
Coordinator
IOANNINA
Greece
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