Objective
The DNA of the eukaryotic cell is accommodated by the structure of chromatin. To administrate the genetic information the cell employs multiple mechanisms regulating protein-DNA transactions in the context of chromatin. Research of the past two decades has demonstrated that chromatin undergoes dynamic changes depending on its functional state: The major chromatin components, the histones, are subject to covalent modifications by specific enzymatic activities, furthermore multi-protein complexes have been de scribed that structurally alter chromatin in ATP-dependent processes. A detailed molecular analysis eventually requires isolation of pure, natural chromatin closely reflecting the in vivo situation. We have established a novel technique to purify single-copy genes from chromosomal loci in the yeast Saccharomyces cerevisiae to near homogeneity, conserving the chromatin structure of distinct transcriptional states.
Future research pursues two lines of investigations:
(i) Determination of structure and composition of natural chromatin in different functional states by electron microscopy and mass spectrometry
(ii) Description of the functional interplay between chromatin remodelling and transcription using isolated natural chromosomal domains and purified protein factor in vitro
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences physical sciences optics microscopy electron microscopy
- natural sciences biological sciences genetics RNA
- natural sciences chemical sciences analytical chemistry mass spectrometry
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-12
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IRG - Marie Curie actions-International re-integration grants
Coordinator
REGENSBURG
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.