Objective
The ability to detect extra-cellular stimuli and execute appropriate responses is crucial to all cellular functions. Neurons are specialized, morphologically complex cells that represent the functional unit of the nervous system. Neurons are equipped to respond to a variety of cues that direct proper intercellular wiring during development and the maintenance of long lasting synaptic changes during adult life. Mature neurons that have lost the ability to respond adequately to physiological cues or have became unable to overcome stressful stimuli undergo degenerative changes that result in abnormal function and eventually death. Neurotrophins comprise a family of peptide growth factors that sculpt the vertebrate nervous system by regulating cell growth, survival, proliferation and differentiation. One key nuclear target of neurotrophin signalling is the transcription factor CREB. I have previously shown that CREB plays a central role in mediating neurotrophin functions, supporting survival and growth of peripheral neurons.
However, the mechanisms by which neurotrophins regulate such diverse responses and the nature of the underlying nuclear changes are still largely unknown. I have recently obtained preliminary data that a novel, neurotrophin-regulated red ox signalling pathway is involved in modulating nuclear responses in neurons under physiological conditions. In particular, neurotrophin-dependent synthesis of nitric oxide and reactive oxygen species (ROS) regulate gene expression by inducing CREB-DNA binding and initiation of transcription.
The goals of this project are:
1) To characterize the early events leading to neurotrophin-dependent regulation of redox signalling in neurons.
2) To identify the nuclear targets and the nature of posttranslational modifications occurring upon neurotrophin-regulated nitric oxide and ROS synthesis.
3) To investigate the potential role of nitric oxide in modulating key transcriptional events during neuronal development.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences biochemistry biomolecules
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-12
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IRG - Marie Curie actions-International re-integration grants
Coordinator
LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.