Biological diagnostic tools using microsystems and supersensitive magnetic detection

Objective

The objective of the proposed project is to develop new medical diagnostic tools based on the most sensitive detector technologies available today. A common denominator for the technologies is reading out the biological state in the magnetic domain. This will be accomplished by using both magnetic nanoparticles as substrates or tags for biological reactions and reading out the atomic nuclear spin. The latter technology is a development from the inductive readout in Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI). The technology used in this project is a pure magnetic field read-out system, which quite contrary to the inductive method has a sensitivity which is more or less independent of frequency and magnetic field down to very low fields. The several competing technologies will be benchmarked against each other with a model system consisting of biotin and streptavidine in order to gain a unique understanding of the differences and advantages with the different systems. To validate the concept(s), real diagnostic test will be done on in vitro detection of F1 antigen (y. pestis) Mycobacterium tuberculosis in urine samples and detection of Yersinia pestis F1 antigen in environmental samples (bio terrorism). Further to the validation, neuroimaging and instrumentation for diagnosis of neurological diseases will be investigated in vivo.

Fields of science

• engineering and technology › electrical engineering, electronic engineering, information engineering › electronic engineering › sensors
• natural sciences › biological sciences › biophysics
• engineering and technology › medical engineering › diagnostic imaging › magnetic resonance imaging
• engineering and technology › nanotechnology › nano-materials
• natural sciences › physical sciences › electromagnetism and electronics › superconductivity

Programme(s)

• FP6-NMP - Nanotechnologies and nanosciences, knowledge-based multifunctional materials and new production processes and devices: thematic priority 3 under the 'Focusing and integrating community research' of the 'Integrating and strengthening the European Research Area' specific programme 2002-2006.

Topic(s)

• NMP-2004-IST-NMP-2 - Bio-sensors for Diagnosis and Healthcare

Call for proposal

FP6-2004-IST-NMP-2
See other projects for this call

Funding Scheme

STREP - Specific Targeted Research Project

Coordinator

CHALMERS TEKNISKA HOEGSKOLA AB

Address

Chalmersplatsen 4
Goeteborg
Sweden

Links

Participants (12)

IMEGO AB

Sweden

Address

Arvid Hedvalls Backe 4
Goeteborg

Links

KAROLINSKA INSTITUTET

Sweden

Address

Nobels Vaeg 5
Stockholm

Links

KUNGLIGA TEKNISKA HÖGSKOLAN

Sweden

Address

Valhallavägen 79
Stockholm

Links

FORSCHUNGSZENTRUM JUELICH GMBH

Germany

Address

Leo-brandt-strasse
Juelich

Links

JUELICHER SQUID GMBH

Germany

Address

Lankenstrasse 29
Juelich

Links

PHYSIKALISCH-TECHNISCHE BUNDESANSTALT

Germany

Address

Bundesallee 100
Braunschweig

Links

CHEMICELL GMBH

Germany

Address

Wartburgstrasse 6
Berlin

Links

FRIEDRICH-SCHILLER-UNIVERSITAET JENA.

Germany

Address

Fuerstengraben 1
Jena

Links

MICRO-SPHERE S.A.

Switzerland

Address

Via Cantonale
Madonna Del Piano

Links

ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE.

United Kingdom

Address

Egham Hill
Egham, Surrey

Links

DANMARKS TEKNISKE UNIVERSITET

Denmark

Address

Anker Engelundsvej 1, Bygning 101a
Kongens Lyngby

Links

SENOVA GESELLSCHAFT FÜR BIOWISSENSCHAFT UND TECHNIK MBH

Germany

Address

Winzerlaerstr.2
Jena

Links