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Biological diagnostic tools using microsystems and supersensitive magnetic detection

Objective

The objective of the proposed project is to develop new medical diagnostic tools based on the most sensitive detector technologies available today. A common denominator for the technologies is reading out the biological state in the magnetic domain. This will be accomplished by using both magnetic nanoparticles as substrates or tags for biological reactions and reading out the atomic nuclear spin. The latter technology is a development from the inductive readout in Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI). The technology used in this project is a pure magnetic field read-out system, which quite contrary to the inductive method has a sensitivity which is more or less independent of frequency and magnetic field down to very low fields. The several competing technologies will be benchmarked against each other with a model system consisting of biotin and streptavidine in order to gain a unique understanding of the differences and advantages with the different systems. To validate the concept(s), real diagnostic test will be done on in vitro detection of F1 antigen (y. pestis) Mycobacterium tuberculosis in urine samples and detection of Yersinia pestis F1 antigen in environmental samples (bio terrorism). Further to the validation, neuroimaging and instrumentation for diagnosis of neurological diseases will be investigated in vivo.

Call for proposal

FP6-2004-IST-NMP-2
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Coordinator

CHALMERS TEKNISKA HOEGSKOLA AB
Address
Chalmersplatsen 4
Goeteborg
Sweden

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Participants (12)

IMEGO AB
Sweden
Address
Arvid Hedvalls Backe 4
Goeteborg

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KAROLINSKA INSTITUTET
Sweden
Address
Nobels Vaeg 5
Stockholm

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KUNGLIGA TEKNISKA HÖGSKOLAN
Sweden
Address
Valhallavägen 79
Stockholm

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FORSCHUNGSZENTRUM JUELICH GMBH
Germany
Address
Leo-brandt-strasse
Juelich

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JUELICHER SQUID GMBH
Germany
Address
Lankenstrasse 29
Juelich

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PHYSIKALISCH-TECHNISCHE BUNDESANSTALT
Germany
Address
Bundesallee 100
Braunschweig

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CHEMICELL GMBH
Germany
Address
Wartburgstrasse 6
Berlin

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FRIEDRICH-SCHILLER-UNIVERSITAET JENA.
Germany
Address
Fuerstengraben 1
Jena

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MICRO-SPHERE S.A.
Switzerland
Address
Via Cantonale
Madonna Del Piano

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Links
ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE.
United Kingdom
Address
Egham Hill
Egham, Surrey

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DANMARKS TEKNISKE UNIVERSITET
Denmark
Address
Anker Engelundsvej 1, Bygning 101a
Kongens Lyngby

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SENOVA GESELLSCHAFT FÜR BIOWISSENSCHAFT UND TECHNIK MBH
Germany
Address
Winzerlaerstr.2
Jena

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