Objective
The D-enantiomer of the amino acid serine is a novel neural modulator released by glial cells within the central nervous system (CNS). Like glycine, D-serine is a coagonist of the glutamatergic N-methyl-D-aspartate (NMDA) receptor. D-serine is necessary fo r NMDA-receptor activation in the hippocampus and could play a critical role in synaptic plasticity, learning and memory or the pathophysiology of brain ischemia. However, the physiological function and the regulation of D-serine release in the CNS are sti ll poorly understood. Through the development of an original D-serine microsensor, I will measure the extracellular concentration of D-serine in brain slices or in the CNS of freely moving rats. The microsensor will be composed of a carbon fiber covered wi th the enzyme D-amino acid oxidase (D-AAOx). D-AAOx selectively degrades D-serine while producing H2O2 that can be detected by the carbon fiber as an index of the ambient D-serine concentration. Using this microsensor, I will determine the kinetics of D-se rine release and clearance in the CNS and examine the possibility of a functional coupling between neuronal activity and D-serine release by astrocytes. In particular, I will investigate whether stimulation of Schaffer collaterals can evoke the release of D-serine in area CA1 of the hippocampus, and whether D-serine release is correlated with the induction of long-term potentiation. By implanting this microsensor in anesthetized or freely moving rats, I will monitor D-serine release during behavioral tasks such as spatial or emotional learning, and in pathological situations like brain ischemia. Finally, the development of this microsensor will pave the way for the in vivo evaluation of potential drugs aimed at modulating D-serine levels. Overall, this proje ct will help understand the mechanisms and functions of D-serine release in the CNS and contribute to the development of new pharmacological tools targeting D-serine.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine neurology epilepsy
- medical and health sciences basic medicine physiology pathophysiology
- medical and health sciences basic medicine pathology
- medical and health sciences basic medicine neurology stroke
- medical and health sciences clinical medicine psychiatry schizophrenia
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-12
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IRG - Marie Curie actions-International re-integration grants
Coordinator
PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.