This project aims to discover protein inhibitors of complex biological processes and the characterization of their molecular targets. We plan to screen plant cDNA libraries for the presence of encoded proteins that inhibit or activate signal transduction pathways in mammalian immune system cells. This approach will be similar to classical mutagenic genetic screening or the recently popular chemical genetic screening for effectors of signal transduction pathways.
The completion of the genome sequencing efforts for multiple species has recently resulted in a wealth of information that can be used in screens for novel polypeptide drugs. Complex plant genomes contain information that can be mined for inhibitors and activators of mammalian signal transduction pathways. Discovery of plant factors that interact with and modify mammalian signal transduction pathways will not only enhance our knowledge of how these pathways work, but also will be valuable for drug discovery. The discovery of plant factors that interact with mammalian signal transduction pathways will also enhance our knowledge of the signal transduction pathways in plants.
Field of science
- /natural sciences/biological sciences/biochemistry/biomolecules/proteins
- /natural sciences/biological sciences/cell biology/cell signaling
- /medical and health sciences/basic medicine/immunology
Call for proposal
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