Objective
HeartRepair uses the lessons of the embryo to answer the crucial developmental questions regarding heart muscle cell differentiation and develop techniques aimed at harnessing stem cells and or recruiting non-damaged myocardial cells from the infarcted heart to facilitate cardiac repair.
Myocardial infarction is the leading cause of congestive heart failure mainly caused by excessive smoking and bad dietary habits. However, the cause of the subsequent heart failure is simple, massive cardiomyocyte necrosis which fatally perturbs heart function. However, an effective therapeutic approach is simple: replacement of damaged myocardium with viable cardiomyocytes.
Recent advances in the field of stem cell replacement therapies, specifically cardiomyocyte regeneration, gains grace as a realistic alternative for congestive heart repair. Major publications revolve around transplantation trials carried out using either embryonic stem cells or bone marrow derived stem cells. However, Field serious questions the current scientific approach to this research and more importantly if, using current techniques and knowledge, such a goal can realistically ever be reached. Realization of this aim will only be achieved by understanding the underlying principles of cardiac muscle cell formation; the mission statement of HeartRepair.
HeartRepair addresses four R&D themes:
1. Genes for heart repair and plasticity, integrating clinical knowledge based genome sequencing to identify genes involved in heart development;
2. Diversification of cardiac progenitor cells, examining the genetics of cardiac muscle cell formation by exploring the process of cardiomyogenesis and subsequent differentiation;
3. Cell interaction and cardiac reprogramming, exploring the details and signals necessary to facilitate an redirect the cardiac fibroblast cell lineage for repair recruitment;
4. Cardiac rejuvenation, to develop techniques to facilitate and speed repair of damaged, not yet necrotic.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences clinical medicine cardiology
- medical and health sciences clinical medicine transplantation
- medical and health sciences clinical medicine embryology
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-LIFESCIHEALTH-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
AMSTERDAM
Netherlands
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Participants (21)
MÜNCHEN
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NEWCASTLE UPON TYNE
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N/A HEIDELBERG
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PARIS
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PARIS
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ROMA
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MILAN
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LONDON
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JAEN
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HANNOVER
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UTRECHT
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MÁLAGA
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9503 LEIDEN
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ZURICH
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GOTHENBURG
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FRANKFURT
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PADOVA
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300 THE HAGUE
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MADRID
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E-28029 MADRID
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BERLIN
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