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Pluripotency associated genes to de-differentiate neural cells into pluripotent cells

Objective

A first step to regenerative medicine is to find a means to cause controlled de-differentiation of adult tissue. Plurigenes aims at achieving major breakthroughs in the discovery and understanding of the function of genes controlling pluripotency in the central nervous system. These later could enable the de-differentiation of terminally differentiated neural cells into pluripotent cells through transgenesis, a goal that fully meets the requirements of LSH-2004-1.1.0-1. Plurigenes will start by identifying candidate genes in model organisms, following original approaches involving screens performed by in situ hybridations on well characterised neural structures or by gain of function analysis. As pointed out in LSH-2004-1.1.0-1, innovative technologies of transgenesis and imaging in several model organisms will be settled to reach this goal. The project will first characterise in vitro and in vivo the functions of candidate genes involved in the maintenance of pluripotency. On selected genes, it will then validate the possibility to restore the pluripotency of terminally differentiated cells through transgenesis of the candidate genes. Finally, Plurigenes will identify molecular partners and related pathways associated with pluripotency. The project will result in the identification of evolutionarily conserved genes associated with cellular pluripotency; improved methods for transgenesis in fish and ascidians and innovative methods for cell imaging and finally, protocols for the de-differentiation of neural cells.

Field of science

  • /natural sciences/biological sciences/neurobiology

Call for proposal

FP6-2004-LIFESCIHEALTH-5
See other projects for this call

Funding Scheme

STREP - Specific Targeted Research Project

Coordinator

INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
Address
147, Rue De L'université
Paris
France

Participants (7)

EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
Address
Meyerhofstraße 1
Heidelberg
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Rue Michel Ange, 3
Paris
STAZIONE ZOOLOGICA "ANTON DOHRN"
Italy
Address
Villa Comunale
Napoli
UNIVERSITY OF WUERZBURG
Germany
Address
Sanderring 2
Wuerzburg
ONCODESIGN
France
Address
20 Rue Jean Mazen
Dijon
MEDICAL RESEARCH COUNCIL
United Kingdom
Address
20, Park Crescent
London
UNIVERSITY OF MILANO BICOCCA
Italy
Address
Piazza Dell'ateneo Nuovo, 1'
Milan