Objective With support from two successive, framework V, EU sponsored consortia, we have developed an in vivo targeting approach for dendritic cells (DC) applicable to protein vaccines, DNA vaccines, and viral vector vaccines. Antibodies directed against the DC-spec ific, endocytic receptor DEC-205 allowed efficient uptake and presentation of antigens coupled to the antibodies by the targeted DCs. Providing a costimulatory signal resulted in potent antiviral immune responses. Given the urgent need for an HIV vaccine, the potential of this innovative vaccine approach should be evaluated as quickly as possible. Therefore, the aims of the current application of the consortium are to determine the efficacy of DEC-205-targeted protein-, DNA-, and viral vector vaccines in an imal models and to understand requirements for and mechanisms of protection. Fields of science natural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicineimmunologymedical and health scienceshealth sciencesinfectious diseasesRNA virusesHIVmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) LSH-2004-2.3.0-1 - Development of new HIV/AIDS vaccine approaches Call for proposal FP6-2004-LIFESCIHEALTH-5 See other projects for this call Funding Scheme IP - Integrated Project Coordinator RUHR-UNIVERSITAET BOCHUM EU contribution No data Address Universitaetsstrasse 150 BOCHUM Germany See on map Total cost No data Participants (8) Sort alphabetically Sort by EU Contribution Expand all Collapse all SWEDISH INSTITUTE FOR INFECTIOUS DISEASE CONTROL Sweden EU contribution No data Address Nobels väg 18 STOCKHOLM See on map Links Website Opens in new window Total cost No data DEUTSCHES PRIMATENZENTRUM Germany EU contribution No data Address Kellnerweg 4 GOETTINGEN See on map Links Website Opens in new window Total cost No data BERNHARD-NOCHT-INSTITUTE FOR TROPICAL MEDICINE Germany EU contribution No data Address Bernhard-Nocht-Straße 74 HAMBURG See on map Links Website Opens in new window Total cost No data INSTITUTE FOR RESEARCH IN BIOMEDICINE Switzerland EU contribution No data Address Via Vincenzo Vela 6 BELLINZONA See on map Links Website Opens in new window Total cost No data GENEART GMBH Germany EU contribution No data Address Josef-Engert-Straße 9 REGENSBURG See on map Links Website Opens in new window Total cost No data INNSBRUCK MEDICAL UNIVERSITY Austria EU contribution No data Address Fritz-Pregl-Straße 3 INNSBRUCK See on map Links Website Opens in new window Total cost No data CHARITÉ, UNIVERSITÄTSMEDIZIN BERLIN Germany EU contribution No data Address Schumannstr. 20-21 BERLIN See on map Links Website Opens in new window Total cost No data UNIVERSITÉ DES MONTAGNES Cameroon EU contribution No data Address Institute of Health Sciences 208 BANGANGTÉ See on map Total cost No data