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Pulmonary Hypertension: Functional Genomics and Therapy of Lung Vascular Remodelling

Objective

Pulmonary hypertension (PH) describes devastating diseases, comprising idiopathic and secondary forms, which cause breathlessness and premature death, representing a major burden on healthcare systems. Extensive lung vascular remodelling with loss of vessel patency is the underlying pathomechanism. PULMOTENSION integrates the top EU Centres in PH and lung vascular biology in a multidisciplinary approach, aiming to combat and finally cure PH. The expertise of all members extends from the initial discovery of gene mutations causative of PH to having established new therapeutic regimen of PH. We will uncover underlying molecular pathways, identify distinct targets for anti-remodelling therapy, foster drug development based on these targets, and test these new treatment options in preclinical and clinical trials. The presented project includes a) genetics of PH, b) functional genomics and proteomics to unravel the molecular pathways underlying vascular remodelling, c) characterisation of the cross-talk between different cells and signalling pathways involved, d) preclinical trials in PH models including transgenics, e) a European PH Tissue Bank and Registry, f) conversion of target discovery into drug design and exploitation, g) development of non-invasive clinical tools for monitoring lung vascular remodelling in patients, h) a Clinical Trial Network to conduct phase I/II(III) studies focussing on anti- and reversal of remodelling in PH patients, and i) promotion of a world-leading infrastructure for scientific and technical competence in the field of PH, including training and mobility programs, technology transfer in alliance with industry and exploitation facilities. Gender issues will be particularly addressed, as many PH forms have a female preponderance. Hence, this ambitious translational research programme will span from molecules to patients to the benefit of molecular understanding and new treatments of PH, a prototype disease of vascular remo

Call for proposal

FP6-2004-LIFESCIHEALTH-5
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Funding Scheme

IP - Integrated Project

Coordinator

JUSTUS-LIEBIG-UNIVERSITY GIESSEN
Address
Ludwigstrasse 23
Giessen
Germany

Participants (30)

ALPHALYSE A/S
Denmark
Address
Unsbjergvej 2A
Odense
NYCOMED GMBH
Germany
Address
Byk Gulden Str. 2
Konstanz
DR. RIETHMÜLLER M/R/S GMBH
Germany
Address
Mittelweg 27
Frankfurt/main
DUALSYSTEMS BIOTECH AG
Germany
Address
Winterthurerstrasse 190
Zurich
GENOLYZE LTD
Finland
Address
Lemminkäisenkatu 14-18 A
140 Turku
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
France
Address
Avenue Victoria 3
Paris
IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE, LONDON
United Kingdom
Address
Exhibition Road, South Kensington
London
LEA MEDIZINTECHNIK GMBH
Germany
Address
Winchesterstr. 2
Giessen
LUXCEL BIOSCIENCES LTD.
Ireland
Address
22A Ballymany Park
Newbridge, Co. Kildare
MEDICAL SCHOOL OF HANNOVER
Germany
Address
Carl-neuberg-str. 1
6870 Hannover
MEDICAL UNIVERSITY GRAZ
Austria
Address
Auenbruggerplatz 2
Graz
MEDICAL UNIVERSITY OF VIENNA
Austria
Address
Spitalgasse 23
Vienna
BIOSPRING GMBH
Germany
Address
Alt Fechenheim
Frankfurt Am Main
GREATER GLASGOW HEALTH BOARD
United Kingdom
Address
300 Balgrayhill Road
Glasgow
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Address
University Offices, Wellington Square
Oxford
UNIVERSITY COLLEGE LONDON
United Kingdom
Address
Gower Street
London
THE CHANCELLORS, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Address
The Old Schools, Trinity Lane
Cambridge
UNIVERSITY OF GLASGOW
United Kingdom
Address
University Avenue
Glasgow
UNIVERSITY OF IOANNINA, MEDICAL SCHOOL
Greece
Address
University Campus
1186 Ioannina
KING´S COLLEGE LONDON
United Kingdom
Address
Strand
London
UNIVERSITY OF SEVILLA
Spain
Address
C/ San Fernando 4
Sevilla
UNIVERSITY OF ZURICH
Switzerland
Address
Rämistrasse 71
Zurich
ALMA MATER STUDIORUM - UNIVERSITÀ DI BOLOGNA
Italy
Address
Via Zamboni 33
Bologna
CHARITÉ - UNIVERSITÄTSMEDIZIN BERLIN
Germany
Address
Schumannstarsse 20-21
Berlin
HOSPITAL CLINÍC I PROVINCIAL DE BARCELONA
Spain
Address
C/ Villarroel, 170
Barcelona
INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MEDICALE
France
Address
101 Rue De Tolbiac
Paris
TRANSMIT GESELLSCHAFT FÜR TECHNOLOGIETRANSFER MBH
Germany
Address
Kerkrader Strasse 3
Giessen
UNIVERSITÄTSKLINIKUM DUISBURG-ESSEN
Germany
Address
Hufelandstr. 55
Essen
UNIVERSITÄTSKLINIKUM HEIDELBERG
Germany
Address
Im Neuenheimer Feld 672
Heidelberg
UNIVERSITÉ LIBRE DE BRUXELLES
Belgium
Address
Avenue Franklin Roosevelt 50
Brussels