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Hepatic and adipose tissue and functions in the metabolic syndrome

Objective

The Metabolic Syndrome is a major risk marker for type 2 diabetes and for cardiovascular disease. Recent evidence suggests a crucial role for fat accumulation in the liver in the development of the Metabolic Syndrome. The hypothesis of the HEPADIP project is that this reflects an alteration in metabolic relationships or the signalling between adipose tissue and liver. The project objectives are therefore to address the role of adipose tissue and the liver, and the interaction between them, in the development of the disturbances of lipid metabolism, insulin signalling, and glucose homeostasis in the Metabolic Syndrome in order to identify, validate and develop novel targets for diagnosis, characterization, prevention and treatment of the syndrome. The Consortium comprises of 26 participants, 6 of which are SMEs, from 11 European countries. The project is organised in seven lines of research for the study of the biology of adipose tissue and the liver, the integrated function of the adipose tissue - liver axis in rodent models and in humans, and clinical and genetic epidemiology of the syndrome. Studies will be integrated across all levels from the molecular/genetic level, to the whole organism, and to the human population. The strategy emplies interactions between a hypothesis-driven and an explorative "omics" approach. Considerable amounts of data from genomics, transcriptomics, proteomics and metabolomics will be generated, and they will be integrated and analyzed with the novel "omics" and bioinformatics technologies. At a later stage, further integration will take place with validation and development of novel targets, and SMEs will play a key role in this phase. The Metabolic Syndrome may differ in its characteristics between men and women, and study design and analysis will address this wherever relevant. The HEPADIPproject will have the best possible prior likelihood of providing tools to combat the Metabolic Syndrome.

Call for proposal

FP6-2004-LIFESCIHEALTH-5
See other projects for this call

Funding Scheme

IP - Integrated Project

Coordinator

REGION HOVEDSTADEN
Address
Kongens Vænge 2
Hillerød
Denmark

Participants (23)

KAROLINSKA INSTITUTET
Sweden
Address
Nobels Väg 5
N/A Stockholm
INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
France
Address
101 Rue De Tolbiac
Paris
TECHNISCHEN UNIVERSITÄT MÜNCHEN
Germany
Address
Arcisstr 21
Muenchen
GÖTEBORGS UNIVERSITET
Sweden
Address
Vasaparken
100 Göteborg
CHARLES UNIVERSITY IN PRAGUE, THIRD FACULTY OF MEDICINE
Czechia
Address
Ruska 87
Praha 10
CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS
Spain
Address
Parque Tecnologico De Bizkaia, Edificio 801 A
Derio, Bizkaia
VRIJE UNIVERSITEIT BRUSSEL
Belgium
Address
Pleinlaan 2
Brussels
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Address
The Olds Schools, Trinity Lane
Cambridge
UNIVERSITÉ DE LAUSANNE
Switzerland
Address
Bâtiment Du Rectorat Et De L'administration (Bra)
Lausanne
INSTITUT PASTEUR DE LILLE
France
Address
1, Rue Du Professeur Calmette
245 Lille
UNIVERSITY HOSPITAL GRONINGEN
Netherlands
Address
Hanzeplein 1
PO Box 30001 Groningen
VTT VALTION TEKNILLINEN TUTKIMUSKESKUS
Finland
Address
Vuorimiehentie 5
1000 Espoo
CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Address
University Offices, Wellington Square
Oxford
HELSINKI UNIVERSITY CENTRAL HOSPITAL
Finland
Address
Stenbäckinkatu 9
100 Helsinki
UNIVERSITY OF TURKU
Finland
Address

Turku
UNIVERSITEIT ANTWERPEN
Belgium
Address
Prinsstraat 13
Antwerpen
NOVO NORDISK A/S
Denmark
Address
Novo Allé
Bagsværd
DIGILAB BIOVISION GMBH
Germany
Address
Feodor-lynen-strasse 5
Hannover
GENFIT
France
Address
Parc Eurasanté - 885, Avenue Eugène Avinée
Loos
ONE WAY LIVER GENOMICS, SL
Spain
Address
Parque Tecnologico Bizkaia. Edificio 801 A.
Derio
PROTEOMIKA S.L.
Spain
Address
Parque Tecnologico Zamudio - 801B
Derio
RHEOSCIENCE A/S
Denmark
Address
Glerupvej 2
Roedovre
REGION NORDJYLLAND
Denmark
Address
Hobrovej 42A
365 Aalborg