Objective
VirApt addresses the need for novel therapeutic and prophylactic interventions against HIV-infection to limit the spread and the devastating effects of the global AIDS epidemic on societies in developing countries, and to provide therapeutic options in t he developed world as resistance to multi-drug treatment increases. In particular, the project aims to generate novel antiviral RNA aptamers that effectively inhibit entry of HIV. Aptamers are relatively short (12-30 base) single-stranded oligonucleotide s that assume defined, stable conformations and bind tightly to very specific targets. VirApt will primarily focus on aptamers that target membrane fusion, but will also endeavour to select aptamers that inhibit HIV entry at the level of receptor or co-r eceptor binding. The aptamers will be developed along three lines: as an antiviral drug, as a topical microbicide and as a basis for the design of a small molecular weight entry inhibitor. In VirApt, European expertise required to reach these goals was a ssembled, including a group experienced in aptamer isolation (Peter Stockley, Leeds), an SME that focuses on the development of antiviral therapies (Dorothee von Laer, Vision7, Hannover) and experts in structure analysis (Felix Rey, Paris). The selection of oligonucleotide aptamers is a basic and important platform technology from which products with a broad range of different applications will be developed. VirApt can help promote this crucial technology in Europe.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences infectious diseases RNA viruses HIV
- natural sciences biological sciences genetics RNA
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antivirals
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-LIFESCIHEALTH-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BURGWEDEL
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.