Objective Primary bone tumours are rare, accounting ~0.2% of the cancer burden. Children and young adolescents are frequently affected. Their aggressiveness has major impact on morbidity and mortality. Though progress has been made in pathological and genetic typing, the aetiology is largely unknown. Though advances in therapeutic approaches increased survival, significant numbers of patients (~40%) still die. Within the EuroBoNeT integration will be achieved by staff exchange and website-based discussion forums to increase and disseminate knowledge of primary bone tumours at the molecular level for development of new tools for patient care and cure and technology. With this integration exchange of material (virtual BioBank), Standard Operating Protocols and the use of technology platforms will enable us to obtain statistical significant datasets, otherwise not achievable due to the rareness and large number of sub entities.A joint programme will contribute in obtaining molecular portraits of tumours, separated in 4 research lines (RL). In each RL the biology of the separate group (RL1: cartilaginous tumours; RL2: osteogenic tumours and related sarcomas; RL3: osteoclastogenesis and Giant cell tumours of bone; and RL4: Ewing family of tumours) will be examined by genome wide expression and genomic aberration studies. More specific hypothesis driven approaches will be investigated by RNA/protein expression and mutation analysis. Knowledge on normal growth and differentiation will be gathered through in vitro studies.This would lead to further understanding and identification of markers for malignant transformation and/or progression, as well as identification of therapeutic targets. Next to research, dissemination of knowledge will be achieved by training courses on bon e and soft tissue pathology for all interested. The last is required since patients usually do not present themselves at centres, which necessitates spreading of knowledge. Fields of science social sciencessociologydemographymortalitymedical and health sciencesclinical medicineoncologymedical and health sciencesbasic medicinepathologynatural sciencesbiological sciencesgeneticsRNAnatural sciencesbiological sciencesgeneticsgenomes Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) LSH-2004-2.2.0-1 - Development of European networks to promote research into uncommon cancers in adults and children Call for proposal FP6-2004-LIFESCIHEALTH-5 See other projects for this call Funding Scheme NoE - Network of Excellence Coordinator LEIDEN UNIVERSITY MEDICAL CENTER Address Albinusdreef 2 9600 Leiden Netherlands See on map Links Website Opens in new window EU contribution € 0,00 Participants (25) Sort alphabetically Sort by EU Contribution Expand all Collapse all ISTITUTI ORTOPEDICI RIZZOLI Italy EU contribution € 0,00 Address Via di barbiano 1/10 Bologna See on map Links Website Opens in new window HELSINKI UNIVERSITY CENTRAL HOSPITAL Finland EU contribution € 0,00 Address Stenbackinkatu 9 100 Helsinki See on map Links Website Opens in new window THE ROYAL ORTHOPAEDIC HOSPITAL NATIONAL HEALTH SERVICE TRUST United Kingdom EU contribution € 0,00 Address Bristal road south, northfield Birmingham See on map Links Website Opens in new window N. GOORMAGHTIGH INSTITUTE OF PATHOLOGY Belgium EU contribution € 0,00 Address De pintelaan 185 Ghent See on map Links Website Opens in new window UNIVERSITEIT ANTWERPEN Belgium EU contribution € 0,00 Address Prinsstraat 13 Antwerp See on map Links Website Opens in new window HEINRICH-HEINE-UNIVERSITY DUESSELDORF, INST. OF PATHOLOGY Germany EU contribution € 0,00 Address Moorenstrasse 5 Duesseldorf See on map Links Website Opens in new window UNIVERSITAT BERN Switzerland EU contribution € 0,00 Address Hochschulstrasse 4 Bern See on map Links Website Opens in new window THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution € 0,00 Address University offices, wellington square Oxford See on map Links Website Opens in new window FUNDACION DE INVESTIGACION DEL CANCER DE LA UNIVERSIDAD DE SALAMANCA (FICUS) Spain EU contribution € 0,00 Address Campus miguel de unamuno s/n Salamanca See on map Links Website Opens in new window OSLO UNIVERSITETSSYKEHUS HF Norway EU contribution € 0,00 Address Forskningsveien 2b Oslo See on map Links Website Opens in new window RIGSHOSPITALET Denmark EU contribution € 0,00 Address Blegdamsvej 9 Copenhagen See on map Links Website Opens in new window LUND UNIVERSITY Sweden EU contribution € 0,00 Address Paradisgatan 5c 117 Lund See on map Links Website Opens in new window KATHOLIEKE UNIVERSITEIT LEUVEN Belgium EU contribution € 0,00 Address Oude markt 13 Leuven See on map Links Website Opens in new window WESTFALISCHE WILHELMSUNIVERSITAT MUNSTER Germany EU contribution € 0,00 Address Domagkstr.17 Munster See on map Links Website Opens in new window UNITA LOCALE SOCIO-SANITARIA N. 9, REGIONE VENETO. HOSPITAL OF TREVISO, DEPARTMENT OF PATHOLOGY Italy EU contribution € 0,00 Address Borgo cavalli n. 42 Treviso See on map SEMMELWEIS UNIVERSITY BUDAPEST Hungary EU contribution € 0,00 Address Ulloi ut 26 Budapest See on map Links Website Opens in new window STIFTUNG ORTHOPADISCHE UNIVERSITATSKLINIK HEIDELBERG Germany EU contribution € 0,00 Address Schlierbacher landstrasse 200 a Heidelberg See on map Links Website Opens in new window PEPSCAN SYSTEMS B.V. Netherlands EU contribution € 0,00 Address Edelhertweg 15 2098 Lelystad See on map Links Website Opens in new window MRC HOLLAND BV Netherlands EU contribution € 0,00 Address Hudsonstraat 68 Amsterdam See on map Links Website Opens in new window ERASMUS MEDICAL CENTER ROTTERDAM Netherlands EU contribution € 0,00 Address Dr molewaterplein 40 1738 Rotterdam See on map Links Website Opens in new window UNIVERSITAT LEIPZIG Germany EU contribution € 0,00 Address Ritterstr.26 Leipzig See on map Links Website Opens in new window UNIVERSITY COLLEGE OF LONDON United Kingdom EU contribution € 0,00 Address Gower street London See on map Links Website Opens in new window PEPSCAN PRESTO B.V. Netherlands EU contribution € 0,00 Address Zuidersluisweg 2 2098 Lelystad See on map Links Website Opens in new window SOLVO BIOTECHNOLOGY INC. Hungary EU contribution € 0,00 Address Béke u. 5/a Szeged See on map Links Website Opens in new window UNIVERSITAT DE VALÈNCIA. ESTUDI GENERAL Spain EU contribution € 0,00 Address Avda. blasco ibanez, 13 22085 Valencia See on map Links Website Opens in new window