Objective This SME coordinated and dominated STREP will investigate new malaria vaccine candidates with the objective of taking at least one through to GLP pilot scale up. The most promising candidates will undergo in vitro and in vivo testing, lead optimisation, safety and toxicology testing according to GLP standards. The combination of efforts presented in this STREP will generate several recombinant measles viruses expressing a variety of malaria antigens based primarily upon MSP-1 and secondarily on AMA-1.In order to maximise on the capabilities of the SMEs and two of the leading European malaria research institutes, this STREP will concentrate on six workpackages: WP1 Project Management; WP2 Development of transgenic humanised mice, Delivery of malaria antigen coding sequences; WP3 Delivery of block 2 malaria antigens; WP4 Hybrid malaria antigen development, Primate challenge studies; WP5 Development of MeVs expressing multiple blood stage malaria antigens; WP6 Validation and Biosafety evaluation of candidate vaccines.The timeframe and budget allocated directly reflect the requirements for such a proposal, including contingency plans. In addition, this STREP application, coordinated by EtnaVax, will compliment the detailed work laid out in other larg er European research projects and proposals. As such it forms an essential stepping-stone in the trans-European malaria vaccine initiative. Fields of science medical and health scienceshealth sciencesinfectious diseasesmalarianatural sciencesbiological sciencesmicrobiologyvirologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesmedical and health sciencesbasic medicinetoxicology Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) LSH-2004-2.3.0-7 - Research in poverty-related diseases by SMEs Call for proposal FP6-2004-LIFESCIHEALTH-5 See other projects for this call Funding Scheme STREP - Specific Targeted Research Project Coordinator ETNA BIOTECH S.R.L. Address Piazza stesicoro 59 Catania Italy See on map EU contribution € 0,00 Participants (3) Sort alphabetically Sort by EU Contribution Expand all Collapse all FOUNDATION BIOMEDICAL PRIMATE RESEARCH CENTRE Netherlands EU contribution € 0,00 Address Lange kleiweg 139 Rijswijk See on map Links Website Opens in new window RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG Germany EU contribution € 0,00 Address Seminarstr. 2 Heidelberg See on map Links Website Opens in new window UNIVERSITY OF EDINBURGH United Kingdom EU contribution € 0,00 Address Old college, south bridge Edinburgh See on map Links Website Opens in new window
