Objective CASCADE was established in 1997 as a collaboration between the investigators of 22 cohorts of persons with well-estimated dates of HIV seroconversion (seroconverters). It is currently a network of epidemiologists, statisticians, virologists and clinicians from lead HIV institutions in 13 European countries, Australia and Canada. Seroconverters are enrolled into the individual cohorts locally and nationally and are typically followed up life-long. CASCADE's main aim is to monitor newly infected individuals, as well as those already enrolled in studies, over the entire duration of HIV infection.The main premise is that through pooling data we are able to address issues which cannot be reliably addressed from single studies alone. Our main objectives are to: estimate survival expectations and assess changes over time; assess the impact of adverse drug reactions on survival, particularly if therapy is started close to seroconversion, and monitor changes in the cause of death over time; examine any changes in the characteristics of the virus over time; determine the impact of transmitted resistance, virus subtype, and host genetic factors on response to therapy and clinical outcome; characterise the foci of recent HIV epidemics in Eastern Europe; characterise initial disease progression in new epidemic areas; examine the effect of co-infection on HIV disease and response to therapy; and develop new techniques to facilitate the co-ordination of HIV clinical research across European cohorts.Follow-up data from seroconverters are unique in providing information from an individual's initial contact with HIV as events can, therefore, be related to roughly the same fixed time point in their disease. Seroconverters thus provide a unique opportunity to study HIV throughout its whole infection period and also enable us to examine the characteristics of recently acquired HIV infection in the population and changes over time. Fields of science natural sciencesbiological sciencesmicrobiologyvirologymedical and health scienceshealth sciencesinfectious diseasesRNA virusesHIVmedical and health sciencesbasic medicinepharmacology and pharmacyadverse drug reactions Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) LSH-2004-2.3.0-8 - European network of HIV/AIDS cohort studies Call for proposal FP6-2004-LIFESCIHEALTH-5 See other projects for this call Funding Scheme CA - Coordination action Coordinator MEDICAL RESEARCH COUNCIL EU contribution No data Address 20 Park Crescent LONDON United Kingdom See on map Links Website Opens in new window Total cost No data Participants (24) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSIDADE NOVA DE LISBOA - INSTITUTO DE HIGIENE E MEDICINA TROPICAL Portugal EU contribution No data Address Rua da Junqueira, 96 LISBOA See on map Links Website Opens in new window Total cost No data UNIVERSIDAD MIGUEL HERNANDEZ Spain EU contribution No data Address Avenida de la Universidad s/n. ELCHE See on map Links Website Opens in new window Total cost No data ROBERT KOCH-INSTITUTE Germany EU contribution No data Address Nordufer 20 BERLIN See on map Links Website Opens in new window Total cost No data ULLEVAL UNIVERSITY HOSPITAL Norway EU contribution No data Address Kirkeveiene 166 OSLO See on map Total cost No data NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS Greece EU contribution No data Address CHR. LADA 6 ATHENS See on map Links Website Opens in new window Total cost No data HOSPICES CANTONAUX - CHUV (CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS) Switzerland EU contribution No data Address Rue du Bugnon 21 LAUSANNE See on map Total cost No data HEALTH PROTECTION AGENCY United Kingdom EU contribution No data Address 7th Floor, Holborn Gate, 330 High Holborn LONDON See on map Links Website Opens in new window Total cost No data THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution No data Address University Offices, Wellington Square OXFORD See on map Links Website Opens in new window Total cost No data SYDDANSK UNIVERSITET Denmark EU contribution No data Address Winsloewparken 17 ODENSE See on map Links Website Opens in new window Total cost No data MUNICIPAL HEALTH SERVICE Netherlands EU contribution No data Address Nieuwe Achtergracht 100 AMSTERDAM See on map Links Website Opens in new window Total cost No data UNIVERSITY COLLEGE LONDON United Kingdom EU contribution No data Address Gower Street LONDON See on map Links Website Opens in new window Total cost No data STATENS SERUM INSTITUTE Denmark EU contribution No data Address Artillerivej 5 COPENHAGEN See on map Links Website Opens in new window Total cost No data TARTU ÜLIKOOL Estonia EU contribution No data Address Ulikooli 18 TARTU See on map Links Website Opens in new window Total cost No data NATIONAL INSTITUTE OF HYGIENE Poland EU contribution No data Address Chocimska 24 WARSAW See on map Links Website Opens in new window Total cost No data SAINT-PETERSBURG PASTEUR INSTITUTE Russia EU contribution No data Address 14 Mira Street SAINT-PETERSBURG See on map Total cost No data IMMUNOCLIN LIMITED United Kingdom EU contribution No data Address Rowlandson House, 289- 293 Ballards Lane LONDON See on map Links Website Opens in new window Total cost No data "PERINATAL PREVENTION OF AIDS INITIATIVE" VOLUNTARY SOCIETY Ukraine EU contribution No data Address 34, Moukachevsky loan, apartment 15 ODESSA See on map Total cost No data INSTITUTO DE SALUD CARLOS III Spain EU contribution No data Address C/ Sinesio Delgado 6 MADRID See on map Links Website Opens in new window Total cost No data ACADEMIC MEDICAL CENTER AT THE UNIVERSITY OF AMSTERDAM Netherlands EU contribution No data Address Meibergdreef 9 1105 AZ AMSTERDAM See on map Links Website Opens in new window Total cost No data INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE INSERM France EU contribution No data Address 101 rue de Tolbiac PARIS See on map Links Website Opens in new window Total cost No data ISTITUTO SUPERIORE DI SANITÀ Italy EU contribution No data Address Viale Regina Elena, 299 ROMA See on map Links Website Opens in new window Total cost No data UNIVERSITÀ DEGLI STUDI DI MILANO Italy EU contribution No data Address VIA FESTA DEL PERDONO 7 MILAN See on map Total cost No data UNIVERSITÉ BORDEAUX 2 France EU contribution No data Address 146, rue Léo Saignat BORDEAUX See on map Links Website Opens in new window Total cost No data UNIVERSITÉ CLAUDE BERNARD LYON 1 France EU contribution No data Address 43 bd du 11 novembre 1918 VILLEURBANNE See on map Links Website Opens in new window Total cost No data