Project description
Preventive treatment for gluten inflammatory symptoms
The E40 enzyme breaks down gluten and is designed to help individuals with Celiac Disease (CeD) and Non-Celiac Gluten Sensitivity (NCGS). It functions in both the stomach and intestine, complementing the benefits of a gluten-free diet (GFD). The EIC-funded Endoprotease 40 (E40) project aims to develop a treatment that prevents symptoms caused by the body’s inflammatory response to gluten, helping people manage accidental gluten exposure and improve their quality of life. It supports a more regular work and social life, reduces anxiety, and enables participation in everyday activities. The enzyme’s ability to degrade gluten to a gluten-free level has been confirmed.
Objective
E40 is a novel gluten degrading enzyme aimed at enhancing the degradation of ingested gluten, particularly in gluten intolerant Celiac Disease (CeD) and Non-Celiac Gluten Sensitivity (NCGS) sufferers.
Different from any other competing enzymes under development, E40 efficiently exerts its gluten degrading activity in both the stomach and the intestine of CeD and NCGS sufferers, supporting the benefits of a Gluten Free Diet (GFD). The final goal is to prevent symptomatology due to the pro-inflammatory reaction triggered by gluten.
E40 will allow sufferers to manage inadvertent gluten exposure and will improve sufferer's Quality of Life, in particular allowing them to normalise their work and social life, reducing anxiety and allowing them to enjoy many everyday activities, like eating in a restaurant, travelling and visiting their friends in their homes.
E40 is produced by an engineered, patented acidic Streptomyces lividans TK24 strain, and directly purified in its mature, functional form. E40 activity has already been confirmed using the validated human simulated digestion INFOGEST assay of real food digestion: E40 gluten degradation leads to a gluten-free status (residual gluten<20ppm as per EC guidelines).
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- medical and health scienceshealth sciencesnutrition
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes
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Programme(s)
- HORIZON.3.1 - The European Innovation Council (EIC) Main Programme
Funding Scheme
HORIZON-EIC-ACC-BF - HORIZON EIC Accelerator Blended FinanceCoordinator
D07 F6DC Dublin
Ireland
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.