Objective
The main objective of this project is the demonstration on a European and worldwide level of the required steps to prepare a new drug for the therapeutical treatment of cancer based on alpharadioimmunotherapy. The products, techniques and installations to be validated are situated in the frame of blood borne cancer treatment both when applying autologous bone marrow transplantation (ABMT) or haematopoietic stem cell rescue (HSCR) ex-corpore and when treating minimal residual disease (MRD) in-vivo.
Alpha-emitting nuclides and their daughter products will be used because of their favourable characteristics for the subject application (high linear energy transfer and therefore good cancer cell killing efficiency, short range and therefore minimal healthy cell killing). The short half-life of the alpha-emitting nuclide 213 Bi (45.6 minutes) also minimises the residual radioactivity both for the ex-corpore and the in-vivo treatment. The selection of B-cell malignancies for the demonstration of this innovative cancer therapy is based on the fact that blood and/or bone marrow borne cancers are the prime candidates to search for new purging techniques ex-corpore to reduce the residual cancer cell burden and the fact that they are ideally suited for alpha-immunotherapeutical treatment (e.g. for minimal residual disease) in-vivo using short lived radioisotopes.
Non-Hodgkin's Lymphoma (NHL) was selected based on the finding that most patients with advanced-stage follicular lymphoma cannot be cured with conventional cytotoxic therapy and that the presence of minimal residual disease in bone marrow is a negative prognostic factor. For NHL the CD22, CD19 and CD20 antigen selective antibodies are well documented and some were tested already in their coupling to iodine or yttrium isotopes. The increase of both the awareness and potential acceptance of this therapy are envisaged by implementing quality controlled production and purification, the in-vitro and in-vivo testing, the ex-corpore evaluation and phase 1 clinical trials of the alpha-radiopharmacon.
This project will validate the products, techniques and installations as described and offer an approved supplementary treatment. In a second step, the use in-vivo will be evaluated by implementing animal testing BALB/C mice will be used for general safety testing, biodistribution, toxicology and histopathology. Dose analysis of the radioimmunoconjugate administered to BALC/C mice will be made and extrapolated to prepare for clinical phase 1 testing on patients having undergone all other approved therapies without success. Patient treatment is planned in a medical equipped facility having the license to work with alpha-emitters. Because of the short half-life of the isotopes used, the patients could however quickly be transported to a normal hospital for further medical follow-up.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences inorganic chemistry transition metals
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences clinical medicine oncology
- medical and health sciences clinical medicine transplantation
- medical and health sciences basic medicine toxicology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
69115 HEIDELBERG
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.