Objective
The regulation of cell division and survival is central to immune regulation, and traditionally the analysis of these processes has been qualitative and descriptive. Recently developed techniques that allow one to follow antigen-specific T and B cells labe led with the dye CFSE over time have stimulated renewed interest in lymphocyte kinetics. Despite the widespread use of this labeling technique in immunology, the proper interpretation of labeling data is difficult and requires analysis with appropriate ma thematical models. We propose to develop efficient mathematical methods to quantify the population kinetics of lymphocytes during immune responses based on the CFSE labeling technique. For this, we plan to use the published data and are collaborating with the laboratory of Dr. Philip D. Hodgkin (Walter and Eliza Hall Institute of Medical Research, Australia), the well-known expert in CFSE labeling technique, to obtain unpublished data on the dynamics of CFSE-labeled T and B lymphocytes in vitro and in viv o. These data will be analyzed using a series of mathematical models with increased levels of complexity. These different models will be used against the data to determine how well the models can describe the data and whether such models are biologicall y realistic. The main theoretical challenge here is to develop mathematical models that are both realistic and contain minimum parameters that can be reliably estimated from the labeling data. The proposed research will allow the coordinator (VVG) to imp rove his skills in developing mathematical models of immune cell dynamics, in application of these models to experimental data, and in learning different techniques of estimation of model parameters. The proposed research will likely result in development of a group of researchers in EU with expertise in the several areas of theoretical immunology including the analysis of data obtained from the dynamics of CFSE labeled lymphocytes.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences sociology demography mortality
- natural sciences biological sciences microbiology virology
- medical and health sciences basic medicine immunology
- natural sciences mathematics applied mathematics mathematical model
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-7
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IIF - Marie Curie actions-Incoming International Fellowships
Coordinator
UTRECHT
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.