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Large scale interactions in brain networks and their breakdown in brain diseases

Objective

The long-term goal of this project is to understand how neuronal assemblies exchange information (functional or neuronal communication), and how variability in neuronal communication explains variability in behavioural performance, both in the intact and injured brain. Communication involves temporal interactions between neuronal assemblies either locally within an area or large-scale between areas. We concentrate on large-scale interaction that occur at two different temporal scales: 'slow' (<0.1 Hz) fluctuations of the blood oxygen level dependent (BOLD) signal easily measured with functional magnetic resonance imaging (fMRI), and 'fast' (1-150 Hz) neuronal oscillations measured at high (multi-unit activity (MUA), local field potential (LFP)) or low (electroencephalography, EEG; magnetoencephalography, MEG) spatial resolution. We wish to demonstrate that these two phenomena are mechanistically linked and are behaviorally significant. A potentially important clinical application is the development of easy-to-use diagnostic measures of neuronal communication for many brain diseases such as stroke, traumatic head injury, multiple sclerosis, and Alzheimer's disease.

Field of science

  • /medical and health sciences/basic medicine/neurology/stroke
  • /medical and health sciences/clinical medicine/radiology/medical imaging/magnetic resonance imaging
  • /medical and health sciences/basic medicine/neurology/multiple sclerosis
  • /medical and health sciences/basic medicine/neurology/alzheimer

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

UNIVERSITA DEGLI STUDI GABRIELE D'ANNUNZIO DI CHIETI-PESCARA
Address
Via Dei Vestini 31
66013 Chieti
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 549 280
Administrative Contact
Maurizio Corbetta (Prof.)

Participants (7)

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 449 999
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maria Vereeken (Ms.)
STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
EU contribution
€ 445 261
Address
Geert Grooteplein Noord 9
6525 EZ Nijmegen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Arthur Willemsen (Dr.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 191 200
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Evelyne Bertino (Ms.)
University College London
United Kingdom
EU contribution
€ 399 964
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kent Lee (Mr.)
FUNDACIO BARCELONA MEDIA
Spain
EU contribution
€ 288 138
Address
Avenida Diagonal 177 - Planta 9
08018 Barcelona
Activity type
Research Organisations
Administrative Contact
Eugenia Fuenmayor (Ms.)
USTAV INFORMATIKY AV CR
Czechia
EU contribution
€ 254 200
Address
Pod Vodarenskou Vezi 271/2
182 07 Praha
Activity type
Research Organisations
Administrative Contact
Milan Palus (Dr.)
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Germany
EU contribution
€ 400 200
Address
Martinistrasse 52
20251 Hamburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Andreas Karl Engel (Prof.)