Apoptosis systems biology applied to cancer and AIDS. An integrated approach of experimental biology, data mining, mathematical modelling, biostatistics, systems engineering and molecular medicine

Project Information

APO-SYS

Grant agreement ID: 200767

Project closed

Start date 1 February 2008

End date 31 January 2012

Funded under

• Specific Programme "Cooperation": Health

Total cost € 14 780 447,52

EU contribution € 11 000 000,00

Coordinated by

KAROLINSKA INSTITUTET
Sweden

Objective

A Europe-wide consortium of experimental biologists, biomathematicians, biostatisticians, computer scientists and clinical scientists will team up to approach cell death pathways in health and disease, placing particular emphasis on cancer and AIDS. The consortium will create a unique database integrating existing and accumulating knowledge on lethal signal transduction pathways leading to apoptosis or non-apoptotic (necrotic, autophagic, mitotic) cell death, perform data mining to integrate system-wide analyses on cell death (genome, epigenome, transcriptome, proteome, lipidome data), and use high-throughput methods (“omics”, CHiP-chip and genome-wide siRNA screens) for the experimental exploration of death pathways in human cell lines in vitro and in relevant disease models (in vitro in human cells and in vivo in mice and Drosophila). In addition, the consortium will establish mathematical models of lethal pathways to devise algorithms that predict apoptosis susceptibility and resistance, obtain data (genome, transcriptome, proteome, lipidome) on clinical samples (cancer cell lines, cancer tissues, serum, and blood samples) and perform biostatistical analyses on them in order to demonstrate the contribution of apoptotic process in human cancers and AIDS. Then, the consortium will integrate the knowledge into mathematical models for the optimal interpretation of clinical data, aiming at optimal diagnostic and prognostic performance as well as at the identification of possible therapeutic targets for the treatment of cancer and AIDS.

Fields of science

• medical and health sciences › health sciences › public health › epidemiology › modeling of diseases spread

Keywords

• AIDS
• apoptosis
• cancer
• cell death
• systems biology

Programme(s)

• FP7-HEALTH - Specific Programme "Cooperation": Health

Topic(s)

• HEALTH-2007-2.1.2-4 - Developing an integrated in vitro, in vivo and systems biology modelling approach to understanding apoptosis in the context of health and disease

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

KAROLINSKA INSTITUTET

• EU contribution: € 1 473 182,39
• Address: Nobels Vag 5 ; 17177 Stockholm ; Sweden
• Region: Östra Sverige › Stockholm › Stockholms län
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Per-Olof Larsson (Mr.)
• Total cost: No data

Participants (23)

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

• EU contribution: € 860 000,00
• Address: RUE DE TOLBIAC 101 ; 75654 Paris
• Region: Ile-de-France › Ile-de-France › Paris
• Activity type: Research Organisations
• Administrative Contact: Audrey Laurent (Ms.)
• Total cost: No data

INSTITUT CURIE

France

• EU contribution: € 597 697,60
• Address: RUE D ULM 26 ; 75231 Paris
• Region: Ile-de-France › Ile-de-France › Paris
• Activity type: Research Organisations
• Administrative Contact: Corinne Cumin (Ms.)
• Total cost: No data

ISTITUTO NAZIONALE PER LE MALATTIE INFETTIVE LAZZARO SPALLANZANI-ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO

Italy

• EU contribution: € 580 000,00
• Address: Via Portuense, 292 ; 00149 Roma
• Region: Centro (IT) › Lazio › Roma
• Activity type: Research Organisations
• Administrative Contact: Cinzia Bomboni (Dr.)
• Total cost: No data

VIB VZW

Belgium

• EU contribution: € 530 000,00
• Address: SUZANNE TASSIERSTRAAT 1 ; 9052 ZWIJNAARDE - GENT
• Region: Vlaams Gewest › Prov. Oost-Vlaanderen › Arr. Gent
• Activity type: Research Organisations
• Administrative Contact: Wim Goemaere (Mr.)
• Total cost: No data

UNIVERSITAET ULM

Participation ended

Germany

• EU contribution: € 114 846,06
• Address: HELMHOLTZSTRASSE 16 ; 89081 Ulm
• Region: Baden-Württemberg › Tübingen › Ulm, Stadtkreis
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Frank Gleixner (Mr.)
• Total cost: No data

UNIVERSITE DE LAUSANNE

Switzerland

• EU contribution: € 480 000,00
• Address: QUARTIER UNIL CENTRE - BATIMENT UNICENTRE ; 1015 LAUSANNE
• Region: Schweiz/Suisse/Svizzera › Région lémanique › Vaud
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Nicolas Fasel (Prof.)
• Total cost: No data

KRAEFTENS BEKAEMPELSE

Denmark

• EU contribution: € 470 000,00
• Address: STRANDBOULEVARDEN 49 ; 2100 Koebenhavn
• Region: Danmark › Hovedstaden › Byen København
• Activity type: Research Organisations
• Administrative Contact: David Mollerup (Mr.)
• Total cost: No data

CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE

France

• EU contribution: € 389 687,20
• Address: Rue Laurent Fries 1 ; 67404 Illkirch Graffenstaden
• Region: Grand Est › Alsace › Bas-Rhin
• Activity type: Research Organisations
• Administrative Contact: Katel Schaeffer (Ms.)
• Total cost: No data

WEIZMANN INSTITUTE OF SCIENCE

Israel

• EU contribution: € 530 000,00
• Address: HERZL STREET 234 ; 7610001 Rehovot
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Talia Tzahor (Ms.)
• Total cost: No data

TEKNOLOGIAN TUTKIMUSKESKUS VTT

Finland

• EU contribution: € 380 000,00
• Address: TEKNIIKANTIE 4 A ; 02044 VTT ESPOO
• Activity type: Research Organisations
• Administrative Contact: Jaana Heino (Ms.)
• Total cost: No data

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG

Germany

• EU contribution: € 390 000,00
• Address: IM NEUENHEIMER FELD 280 ; 69120 Heidelberg
• Region: Baden-Württemberg › Karlsruhe › Heidelberg, Stadtkreis
• Activity type: Research Organisations
• Administrative Contact: Bettina Crispin (Ms.)
• Total cost: No data

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

• EU contribution: € 363 059,00
• Address: Meyerhofstrasse 1 ; 69117 Heidelberg
• Region: Baden-Württemberg › Karlsruhe › Heidelberg, Stadtkreis
• Activity type: Research Organisations
• Administrative Contact: Keith Williamson (Mr.)
• Total cost: No data

TEL AVIV UNIVERSITY

Israel

• EU contribution: € 300 000,00
• Address: RAMAT AVIV ; 69978 Tel Aviv
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Lea Pais (Ms.)
• Total cost: No data

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Germany

• EU contribution: € 787 692,00
• Address: HOFGARTENSTRASSE 8 ; 80539 Munchen
• Region: Bayern › Oberbayern › München, Kreisfreie Stadt
• Activity type: Research Organisations
• Administrative Contact: Birgit Knepper-Nicolai (Dr.)
• Total cost: No data

INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH

Austria

• EU contribution: € 470 000,00
• Address: DR BOHRGASSE 3 ; 1030 Wien
• Region: Ostösterreich › Wien › Wien
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Tanja Winkler (Ms.)
• Total cost: No data

SYDDANSK UNIVERSITET

Denmark

• EU contribution: € 459 700,00
• Address: CAMPUSVEJ 55 ; 5230 Odense M
• Region: Danmark › Syddanmark › Fyn
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Jens V. Kierkegaard (Mr.)
• Total cost: No data

ROYAL COLLEGE OF SURGEONS IN IRELAND

Ireland

• EU contribution: € 270 000,00
• Address: ST STEPHEN'S GREEN 123 ; 2 Dublin
• Region: Ireland › Northern and Western › Border
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Barry Mcgowan (Mr.)
• Total cost: No data

UNIVERSITAET GRAZ

Austria

• EU contribution: € 270 004,00
• Address: UNIVERSITATSPLATZ 3 ; 8010 Graz
• Region: Südösterreich › Steiermark › Graz
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Frank Madeo (Prof.)
• Total cost: No data

UNIVERSITE LYON 1 CLAUDE BERNARD

France

• EU contribution: € 300 000,00
• Address: BOULEVARD DU 11 NOVEMBRE 1918 NUM43 ; 69622 Villeurbanne Cedex
• Region: Auvergne-Rhône-Alpes › Rhône-Alpes › Rhône
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Javier Olaiz (Dr.)
• Total cost: No data

UNIVERSITA DEGLI STUDI DELLA CAMPANIA LUIGI VANVITELLI

Italy

• EU contribution: € 269 980,00
• Address: VIALE ABRAMO LINCOLN 5 ; 81100 Caserta
• Region: Sud › Campania › Caserta
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Annunziata Valente (Dr.)
• Total cost: No data

MEDICEL OY

Participation ended

Finland

• EU contribution: € 193 798,61
• Address: HAARTMANINKATU 8 ; 00290 HELSINKI
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Christophe Roos (Dr.)
• Total cost: No data

KLINIKUM DER JOHANN WOLFGANG VON GOETHE UNIVERSITAET

Germany

• EU contribution: € 302 654,00
• Address: THEODOR STERN KAI 7 ; 60596 Frankfurt Am Main
• Region: Hessen › Darmstadt › Frankfurt am Main, Kreisfreie Stadt
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Kseniya Polozheyeva (Ms.)
• Total cost: No data

UNIVERSITE D'AIX MARSEILLE

France

• EU contribution: € 217 699,14
• Address: BOULEVARD CHARLES LIVON 58 LE PHARO ; 13284 Marseille
• Region: Provence-Alpes-Côte d’Azur › Provence-Alpes-Côte d’Azur › Bouches-du-Rhône
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Celine Damon (Ms.)
• Total cost: No data