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OpenTox - An Open Source Predictive Toxicology Framework

Objective

The goal of the OpenTox project is to develop a predictive toxicology framework with a unified access to toxicological data, (Q)SAR models and supporting information. It will provide tools for the integration of data from various sources (public and confidential), for the generation and validation of (Q)SAR models, libraries for the development and integration of new (Q)SAR algorithms, and validation routines. OpenTox will attract toxicological experts without (Q)SAR expertise as well as model and algorithm developers. It will move beyond existing attempts to solve individual research issues, by providing a flexible and user friendly framework that integrates existing solutions and new developments. OpenTox will be relevant for REACH as it gives risk assessors simple access to experimental data, (Q)SAR models and toxicological information that adheres to European and international regulatory requirements. OpenTox will be published as an open source project to allow a critical evaluation of its algorithms, to promote dissemination, and to attract external developers. Facilities for the inclusion of confidential in-house data and for accessing commercial prediction systems will be included. OpenTox will contain high-quality data and (Q)SAR models for chronic, genotoxic and carcinogenic effects. These are the endpoints with the greatest potential to reduce animal testing. The impact of OpenTox will however go beyond REACH and long-term effects, because it will be straightforward to create models for other endpoints (e.g,. sensitisation, liver-toxicity, cardio-toxicity, ecotoxicity). The proposed framework will support the development of new (Q)SAR models and algorithms by automating routine tasks, providing a testing and validation environment and allowing the easy addition of new data. For this reason we expect, that OpenTox will lead to (Q)SAR models for further toxic endpoints and generally improve the acceptance and reliability of (Q)SAR models.

Field of science

  • /medical and health sciences/basic medicine/toxicology

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

DOUGLAS CONNECT
Address
Baermeggenweg
4314 Zeiningen
Switzerland
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 670 400
Administrative Contact
Nicki Douglas (Ms.)

Participants (10)

HELMA CHRISTOPH
Germany
EU contribution
€ 320 640
Address
Talstrasse 20
79102 Freiburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Christoph Helma (Dr.)
IDEACONSULT LIMITED LIABILITY COMPANY
Bulgaria
EU contribution
€ 224 640
Address
Angel Kanchev 4
1000 Sofia
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Vedrin Jeliazkov (Mr.)
ISTITUTO SUPERIORE DI SANITA
Italy
EU contribution
€ 136 800
Address
Viale Regina Elena 299
00161 Roma
Activity type
Research Organisations
Administrative Contact
Rosa Maria Martoccia (Ms.)
TECHNISCHE UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 457 440
Address
Arcisstrasse 21
80333 Muenchen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ulrike Ronchetti (Ms.)
ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Germany
EU contribution
€ 510 720
Address
Fahnenbergplatz
79098 Freiburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Andreas Karwath (Dr.)
NATIONAL TECHNICAL UNIVERSITY OF ATHENS - NTUA
Greece
EU contribution
€ 228 000
Address
Heroon Polytechniou 9 Zographou Campus
15780 Athina
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Yannis Polyzos (Prof.)
DAVID ANTHONY GALLAGHER
United Kingdom
EU contribution
€ 88 800
Address
Park Mews, Park Road 3
BS49 5HR Congresbury
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
David Gallagher (Dr.)
INSTITUTE OF BIOMEDICAL CHEMISTRY - RUSSIAN ACADEMY OF SCIENCES
Russia
EU contribution
€ 186 000
Address
Pogodinskaya Street 10
119121 Moskva
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Poroikov Vladimir (Prof.)
SEASCAPE LEARNING CO PRIVATE LTD
India
EU contribution
€ 54 720
Address
Double Storey, New Rajinder Ngr 271
110060 New Delhi
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Sunil Chawla (Mr.)
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
EU contribution
€ 97 200
Address
Hansastrasse 27C
80686 Munchen
Activity type
Research Organisations
Administrative Contact
Andrea Zeumann (Ms.)