Objective The goal of the OpenTox project is to develop a predictive toxicology framework with a unified access to toxicological data, (Q)SAR models and supporting information. It will provide tools for the integration of data from various sources (public and confidential), for the generation and validation of (Q)SAR models, libraries for the development and integration of new (Q)SAR algorithms, and validation routines. OpenTox will attract toxicological experts without (Q)SAR expertise as well as model and algorithm developers. It will move beyond existing attempts to solve individual research issues, by providing a flexible and user friendly framework that integrates existing solutions and new developments. OpenTox will be relevant for REACH as it gives risk assessors simple access to experimental data, (Q)SAR models and toxicological information that adheres to European and international regulatory requirements. OpenTox will be published as an open source project to allow a critical evaluation of its algorithms, to promote dissemination, and to attract external developers. Facilities for the inclusion of confidential in-house data and for accessing commercial prediction systems will be included. OpenTox will contain high-quality data and (Q)SAR models for chronic, genotoxic and carcinogenic effects. These are the endpoints with the greatest potential to reduce animal testing. The impact of OpenTox will however go beyond REACH and long-term effects, because it will be straightforward to create models for other endpoints (e.g,. sensitisation, liver-toxicity, cardio-toxicity, ecotoxicity). The proposed framework will support the development of new (Q)SAR models and algorithms by automating routine tasks, providing a testing and validation environment and allowing the easy addition of new data. For this reason we expect, that OpenTox will lead to (Q)SAR models for further toxic endpoints and generally improve the acceptance and reliability of (Q)SAR models. Fields of science medical and health sciencesbasic medicinetoxicology Keywords (Q)SAR in silico open source predictive toxicology reduction reduction of animal experiments Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-1.3-3 - Promotion, development, validation, acceptance and implementation of QSARs (quantitative structure-activity relationship) for toxicology Call for proposal FP7-HEALTH-2007-A See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator DOUGLAS CONNECT EU contribution € 670 400,00 Address Baermeggenweg 14 4314 ZEININGEN Switzerland See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Nicki Douglas (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (10) Sort alphabetically Sort by EU Contribution Expand all Collapse all HELMA CHRISTOPH Germany EU contribution € 320 640,00 Address TALSTRASSE 20 79102 FREIBURG See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Christoph Helma (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data IDEACONSULT LIMITED LIABILITY COMPANY Bulgaria EU contribution € 224 640,00 Address ANGEL KANCHEV 4 1000 Sofia See on map Region Югозападна и Южна централна България Югозападен София (столица) Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Vedrin Jeliazkov (Mr.) Links Contact the organisation Opens in new window Total cost No data ISTITUTO SUPERIORE DI SANITA Italy EU contribution € 136 800,00 Address Viale Regina Elena 299 00161 Roma See on map Region Centro (IT) Lazio Roma Activity type Research Organisations Administrative Contact Rosa Maria Martoccia (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data TECHNISCHE UNIVERSITAET MUENCHEN Germany EU contribution € 457 440,00 Address Arcisstrasse 21 80333 Muenchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Ulrike Ronchetti (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ALBERT-LUDWIGS-UNIVERSITAET FREIBURG Germany EU contribution € 510 720,00 Address FAHNENBERGPLATZ 79098 Freiburg See on map Region Baden-Württemberg Freiburg Freiburg im Breisgau, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Andreas Karwath (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ETHNICON METSOVION POLYTECHNION Greece EU contribution € 228 000,00 Address HEROON POLYTECHNIOU 9 ZOGRAPHOU CAMPUS 157 80 ATHINA See on map Region Αττική Aττική Κεντρικός Τομέας Αθηνών Activity type Higher or Secondary Education Establishments Administrative Contact Yannis Polyzos (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data DAVID ANTHONY GALLAGHER United Kingdom EU contribution € 88 800,00 Address Park Mews, Park Road 3 BS49 5HR CONGRESBURY See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact David Gallagher (Dr.) Links Contact the organisation Opens in new window Total cost No data INSTITUTE OF BIOMEDICAL CHEMISTRY - RUSSIAN ACADEMY OF SCIENCES Russia EU contribution € 186 000,00 Address POGODINSKAYA STREET 10 119121 MOSKVA See on map Activity type Higher or Secondary Education Establishments Administrative Contact Poroikov Vladimir (Prof.) Links Contact the organisation Opens in new window Total cost No data SEASCAPE LEARNING CO PRIVATE LTD India EU contribution € 54 720,00 Address DOUBLE STOREY, NEW RAJINDER NGR 271 110060 NEW DELHI See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Sunil Chawla (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV Germany EU contribution € 97 200,00 Address HANSASTRASSE 27C 80686 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Andrea Zeumann (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
