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Strategies TO Prevent Pregnancy-Associated Malaria

Objective

The Partners propose to conduct a cohort study in pregnant women and their newborns to quantify the effects of Pregnancy-Associated Malaria (PAM) and to identify a PAM vaccine candidate. Effects of PAM on the pregnant woman (placental infection and anaemia), the offspring (birth weight reduction), and the infant (increased morbidity and mortality) are well known. Studies underlined the role of P. falciparum variable surface antigens expressed on infected erythrocytes in binding to placenta. A specific immune response against this antigen reduces the effect of PAM during latter pregnancies, making possible to develop a new preventive strategy based on the enhancement of this specific response. This goal will be achieved through cohort studies in 2 endemic areas (West and East Africa), as the mechanisms and the resulting effects may vary with transmission. Biological samples will be collected during pregnancy and infancy to dissect the pathological and immune mechanisms involved, as well as to characterize phenotypically and genetically the infecting parasites, providing a structural basis for anti-PAM vaccine design. The immunopathological effects will be measured in the mothers, their newborns, and the infant, in relation with timing of infection. The ultimate goal is to identify the most immunogenic epitopes of VAR2CSA (the major variable surface antigens of P. falciparum parasites infecting the pregnant women) to be included in such a vaccine. It is anticipated that the product of this project will be directly usable to enter in the pipeline of vaccine development. The 7 Partners of the consortium (5 from 4 EU countries, and 2 from Benin and Tanzania) have a combined history of high class, internationally-recognized research in malaria. All EU teams have huge experience of collaboration with malaria endemic countries institutions and with studies related to malaria in pregnant women, that are also routinely conducted by the 2 African Partners.

Field of science

  • /medical and health sciences/health sciences/infectious disease/malaria
  • /social sciences/sociology/demography/fertility
  • /social sciences/sociology/demography/mortality
  • /humanities/history and archaeology/history

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT
Address
Boulevard De Dunkerque 44 Cs 90009
13572 Marseille
France
Activity type
Research Organisations
EU contribution
€ 634 554
Administrative Contact
Michel Laurent (Prof.)

Participants (6)

KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 421 500
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ivan Kristoffersen (Mr.)
STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
EU contribution
€ 428 646
Address
Geert Grooteplein Noord 9
6525 EZ Nijmegen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Yvonne Poort (Ms.)
UNIVERSITE D'ABOMEY-CALAVI
Benin
EU contribution
€ 539 866
Address
Campus Universitaires D Abomey
01 Abomey Calavi
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sogbadji Joseph Vodouhe (Prof.)
NATIONAL INSTITUTE FOR MEDICAL RESEARCH
Tanzania
EU contribution
€ 692 212
Address
Sokoine Luthuli Drive Ocean Road
255 Dar Es Salaam
Activity type
Research Organisations
Administrative Contact
Martha Lemnge (Dr.)
AYMING
France
EU contribution
€ 49 900
Address
185 Avenue Des Gresillons
92622 Gennevilliers Cedex
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Franck Noumbissie (Mr.)
STOCKHOLMS UNIVERSITET
Sweden
EU contribution
€ 231 240
Address
Universitetsvagen 10
10691 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gelana Yadeta (Mr.)