Objective IBDase addresses the etiology and pathogenesis of inflammatory bowel disease (IBD) with a multidisciplinary plan for innovative diagnosis and therapy focused on mucosal proteases and their inhibitors (P/PIs). The incidence of IBD, a multifactorial disease influenced by environmental factors in a background of complex genetic susceptibility, is rising, particularly among European children. Current therapies lack efficacy and specificity. The gut microflora plays a crucial role in IBD but the cause for this is still poorly understood. Research implicating P/PIs in gut mucosal inflammation requires further mechanistic insight and the P/PIs relevant in human IBD need to be identified. To this end we will identify human mucosal P/PI polymorphisms affecting expression levels and/or activity of P/PIs and analyse their genotype/phenotype associations in IBD patient cohorts across Europe. IBD-associated P/PIs will be characterised by biochemical properties, expression in human clinical samples and manipulation of experimental models. Their interaction with microflora will be examined in animal models with controlled colonisation of the gut and in vitro co-culture models of intestinal mucosa and bacteria. In vivo studies will use targeted, well-established and new mouse models and evaluate zebrafish as an IBD model. Molecular mechanisms for involvement of IBD specific P/PI gene variants in the inflammatory response will be proposed. Therapeutics development will focus on specific inhibition or promotion of proteolysis in the intestinal mucosa, and select at least three validated P/PI of the intestinal mucosa for follow-up in clinical trials. Embracing the concept of tailoring treatment to individual patient characteristics to increase efficacy and reduce side-effects, IBDase strengthens international visibility of IBD related research, policies and industry and fosters IBD related research to the benefit of European society in both patient care and economic interest. Fields of science natural sciencesbiological sciencesmicrobiologybacteriologymedical and health sciencesclinical medicinegastroenterologyinflammatory bowel disease Keywords IBD animal animal model gene polymorphism intestine medicine proteolysis therapy intestine microflora model gene pathogenesis personalised medicine polymorphism IBD microflora pathogenesis personalised proteolysis therapy Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-2.4.5-2 - Inflammatory bowel disease Call for proposal FP7-HEALTH-2007-A See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator UNIVERSITAET BERN Address Hochschulstrasse 6 3012 Bern Switzerland See on map Region Schweiz/Suisse/Svizzera Espace Mittelland Bern / Berne Activity type Higher or Secondary Education Establishments Administrative Contact Daniel Lottaz (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 526 950,00 Participants (9) Sort alphabetically Sort by EU Contribution Expand all Collapse all KATHOLIEKE UNIVERSITEIT LEUVEN Belgium EU contribution € 305 000,00 Address Oude markt 13 3000 Leuven See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Higher or Secondary Education Establishments Administrative Contact Marion Wolpers (Ms.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITE D'AUVERGNE CLERMONT-FERRAND 1 France EU contribution € 247 400,00 Address Boulevard francois mitterand 49 63001 Clermont-ferrand See on map Activity type Higher or Secondary Education Establishments Administrative Contact Laurent Claret (Dr.) Links Contact the organisation Opens in new window Website Opens in new window JOHANNES GUTENBERG-UNIVERSITAT MAINZ Germany EU contribution € 88 400,00 Address Saarstrasse 21 55122 Mainz See on map Region Rheinland-Pfalz Rheinhessen-Pfalz Mainz, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Karl Peter Christian Spath (Dr.) Links Contact the organisation Opens in new window Website Opens in new window PROGENIKA BIOPHARMA SA Spain EU contribution € 533 650,00 Address Parque ibaizabal bidea edificio 504 parque tecnologico derio 48160 Vizcaya bizkaia See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Gorka Ramirez (Dr.) Links Contact the organisation Opens in new window Website Opens in new window ISTITUTO EUROPEO DI ONCOLOGIA SRL Italy EU contribution € 314 550,00 Address Via filodrammatici 10 20121 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Ilaria Foti (Ms.) Links Contact the organisation Opens in new window Website Opens in new window GOETEBORGS UNIVERSITET Sweden EU contribution € 258 200,00 Address Vasaparken 405 30 Goeteborg See on map Region Södra Sverige Västsverige Västra Götalands län Activity type Higher or Secondary Education Establishments Administrative Contact Margareta Ahlqwist (Prof.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITY OF SOUTHAMPTON United Kingdom EU contribution € 387 800,00 Address Highfield SO17 1BJ Southampton See on map Region South East (England) Hampshire and Isle of Wight Southampton Activity type Higher or Secondary Education Establishments Administrative Contact Rachel Green (Ms.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA Italy EU contribution € 175 400,00 Address Via cracovia 50 00133 Roma See on map Region Centro (IT) Lazio Roma Activity type Higher or Secondary Education Establishments Administrative Contact Francesco Pallone (Prof.) Links Contact the organisation Opens in new window Website Opens in new window SCIPROM SARL Switzerland EU contribution € 136 200,00 Address Rue du centre 70 1025 Saint sulpice See on map Region Schweiz/Suisse/Svizzera Région lémanique Vaud Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Kirsten Leufgen (Dr.) Links Contact the organisation Opens in new window Website Opens in new window
