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Targeted Nanosystems for Improving Photodynamic Therapy and Diagnosis of Cancer

Objective

The overall objective of this proposal is the development of one or more nanosystems loaded with Foscan® and conjugated to cancer cell specific ligands for improving the efficacy and selectivity of photodynamic therapy (PDT) and optimise a fluorescence-based tumour imaging approach. At present, PDT with Foscan® can be very effective but is not selective because Foscan® accumulates in the tumour tissue as well as in healthy ones. A great improvement of the therapy can only come from the availability of a carrier able to seek cancer cells and deliver Foscan® selectively to them. Three types of nanosystems, namely, liposomes, silica nanoparticles or poly(lactide-co-glycolide) copolymer nanoparticles, have been selected as potential nanocarriers for the selective delivery of Foscan®. The selection was mainly based on the different chemical nature of these systems, which can affect biocompatibility. During the first part of the project each type of nanosystem will be optimised through in vitro and in vivo tests and leader nanocarriers will be selected and conjugated to cancer cells specific ligands for increasing the selective delivery of Foscan®. The ligands we will use (folic acid, EGF, and antibodies) for targeting the nanosystems find their corresponding receptor over-expressed on the surface of cancer cells, therefore allowing a selective delivery of drugs in these cells. In vitro and in vivo investigations will be carried to demonstrate the validity of our approach and deliver, at project conclusion, a final product which can then be tested clinically. Because of the red fluorescence emitted by Foscan®, once it is selectively accumulated in cancer cells fluorescence based technique can be used for tumour imaging and diagnosis. Therefore we expect to develop a Foscan® loaded nanosystem/s which can be used for improving both therapeutic and tumour imaging approaches.

Field of science

  • /medical and health sciences/clinical medicine/oncology/cancer

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

UNIVERSITA DEGLI STUDI DI PADOVA
Address
Via 8 Febbraio 2
35122 Padova
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 910 538
Administrative Contact
Gerolamo Lanfranchi (Prof.)

Participants (4)

UNIVERZA V LJUBLJANI
Slovenia
EU contribution
€ 357 400
Address
Kongresni Trg 12
1000 Ljubljana
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ales Kolenko (Mr.)
University College London
United Kingdom
EU contribution
€ 524 520
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Greta Borg-Carbott (Ms.)
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
EU contribution
€ 295 700
Address
Hanzeplein 1
9713 GZ Groningen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Elisabeth W.H.M. Eijdems (Dr.)
BIOLITEC AG
Germany
EU contribution
€ 364 960
Address
Winzerlaer Straße 2
D-07745 Jena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Karin Boettcher (Ms.)