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EUROpean consortium on NEUTralising antibodies using gp41

Objective

There is now an increasingly solid body of scientific evidence which demonstrates that the binding of small molecular weight compounds, peptides and antibodies (Abs) to fusion-intermediate conformations of gp41 leads to an inhibition of HIV cell entry. The principal aim of this project is to exploit this information by establishing a platform where gp41-derived vaccine candidates will be designed to elicit neutralising Abs. Several families of immunogens which mimic gp41 in its fusion intermediate conformations are already available and others will be designed using modelisation approaches. Candidates will be submitted to a thorough biophysical characterisation followed by a preclinical development in order to identify the most promising for clinical evaluation. A crucial selection parameter is the capacity of antigens to elicit neutralising Abs using internationally standardized assays. Since sexual transmission accounts for more than 90% of HIV infection, the capacity of Abs to inhibit infection at the mucosal level will also be determined. This cross-disciplinary project gathers top European scientists with expertise in protein engineering and characterisation, adjuvantation, formulation for systemic and mucosal delivery, evaluation of functional antibody response, efficacy testing in animal models, medium to large scale vaccine production as well as conduct of clinical trials in both developed and third-world countries. In contrast to previous more empirical attempts, this project is based on the rational exploitation of the knowledge on the mechanism of HIV entry and is thus a promising approach to generate a protective vaccine. It will be the first European project targeting intermediate conformations of gp41 and it could complement/synergize other international strategies focusing on the membrane proximal region of gp41 or gp140 trimer to induce neutralising Abs or aiming at reducing the viral load by eliciting a cellular immunity against HIV.

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

SANOFI PASTEUR SA
Address
Avenue Pont Pasteur, 2
69007 Lyon
France
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 1 067 425,58
Administrative Contact
Delphine Jullien

Participants (18)

ROBERT KOCH-INSTITUT
Germany
EU contribution
€ 750 871,56
Address
Nordufer 20
13353 Berlin
Activity type
Research Organisations
Administrative Contact
Joachim Denner (Dr.)
UNIVERSIDAD DE GRANADA
Spain
EU contribution
€ 976 782,10
Address
Cuesta Del Hospicio Sn
18071 Granada
Activity type
Higher or Secondary Education Establishments
Administrative Contact
José Antonio Carrillo Miñán (Mr.)
GENEART AG
Germany
EU contribution
€ 284 464,80
Address
Josef-engert-strasse 9
93053 Regensburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Frank Notka (Dr.)
BIONEER A/S
Denmark
EU contribution
€ 285 617,76
Address
Kogle Alle 2
2970 Hoersholm
Activity type
Research Organisations
Administrative Contact
Lars Hagsholm Pedersen (Dr.)
PX'Therapeutics
France
EU contribution
€ 1 429 475,64
Address
15, Rue Des Martyrs
38027 Grenoble
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Delphine Colombet (Dr)
THE QUEEN'S UNIVERSITY OF BELFAST
United Kingdom
EU contribution
€ 494 606,50
Address
University Road Lanyon Building
BT7 1NN Belfast
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Colleen Spence (Ms.)
POLYMUN SCIENTIFIC IMMUNBIOLOGISCHE FORSCHUNG GMBH
Austria
EU contribution
€ 573 602,80
Address
Donaustrasse 99
3400 Klosterneuburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Dietmar Katinger (Dr.)
NEMZETI ELELMISZERLANC-BIZTONSAGI HIVATAL
Hungary
EU contribution
€ 146 950
Address
Keleti Karoly Utca 24
1024 Budapest
Activity type
Other
Administrative Contact
Gábor Kulcsár (Dr.)
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
EU contribution
€ 1 671 433,70
Address
Rue Leblanc 25
75015 Paris 15
Activity type
Research Organisations
Administrative Contact
Etienne Garderet (Mr.)
ST GEORGE'S HOSPITAL MEDICAL SCHOOL
United Kingdom
EU contribution
€ 469 854,26
Address
Cranmer Terrace
SW17 0RE London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Susan Mcpheat
ROYAL FREE LONDON NHS FOUNDATION TRUST
United Kingdom
EU contribution
€ 233 145,10
Address
Pond Street Hampstead
NW3 2QG London
Activity type
Research Organisations
Administrative Contact
Margaret Johnson (Prof.)
LES CENTRES GHESKIO
Haiti
EU contribution
€ 18 029
Address
33 Boulevard Harry Truman
6110 Port-au-prince
Activity type
Research Organisations
Administrative Contact
Jean William Pape (Dr.)
IM PROJET (SUISSE) SARL

Participation ended

Switzerland
Address
Rue De La Fontenette 29
1227 Carouge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Philippe Regis (Mr.)
UNIVERSITE DE STRASBOURG
France
EU contribution
€ 1 199 583,42
Address
Rue Blaise Pascal 4
67081 Strasbourg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sandrine Schott-Carriere (Ms.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 174 250,80
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Sonia Robinet (Ms.)
IM PROJET SAS
France
EU contribution
€ 585 382,40
Address
Porte Du Grand Lyon 6
01707 Neyron
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Philippe Regis (Mr.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 779 270,58
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tatjana Palalic (Ms.)
UNIVERSITY OF SURREY
United Kingdom
EU contribution
€ 825 336
Address
Stag Hill
GU2 7XH Guildford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maria Sega-Buhalis (Ms.)