Objective A detailed understanding of human biology will require not only knowledge of the human genome but also of the human metagenome, defined here as the ensemble of the genomes of human-associated microorganisms. Our proposal focuses on the microorganisms of the gut, which are particularly abundant and complex and have an important role for human health and well-being. We shall implement and integrate the following activities: (i) creation of a reference set of genes and genomes of intestinal microbes, using high fidelity metagenomic sequencing and full genome sequencing of selected bacterial species; (ii) creation of the generic tools, based on the high density DNA arrays and novel ultra-high throughput re-sequencing techniques, to study the variation of human gut microbiota; (iii) use of the tools to search for correlations between the genes present in the gut microbiota and disease, focusing on the inflammatory bowel disease and obesity, the two pathologies of increasing social relevance in Europe; (iv) study of the genes correlated with the disease, both in terms of their function in microbes and their effect on the host, with the focus on host-microbe interactions; (v) development of an informatics resource to store and organize the heterogeneous information generated within the project, such as gene and genome sequences, gene frequencies in healthy and sick individuals or gene functions and also enriched by information relevant to human gut microbiota from the outside of the project; (vi) creation of the bioinformatics tools to carry out the meta-analysis of the information; (vii) creation of an interface with the stakeholders, including an international board to promote cooperation and coordination in the human metagenome field, and general public. Our project will place Europe in a leading position in this field and open avenues to modulate human gut microbiota in a reasoned way, enabling to optimize the health and wellbeing of any individual. Fields of science natural sciencesbiological sciencesgeneticsDNAmedical and health sciencesbasic medicinemedical geneticsnatural sciencesbiological sciencesgeneticsgenomes Keywords Metagenomics database inflammatory bowel disease micrarray-based profiling tools obesity reference set of genes and genomes o reference set of genes and genomes of human intestine microbes sequencing-based profiling tools Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-2.1.1-4 - Characterisation and variability of the microbial communities in the Human Body Call for proposal FP7-HEALTH-2007-A See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT Address 147 rue de l'universite 75007 Paris France See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact François Chambelin (Mr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (15) Sort alphabetically Sort by EU Contribution Expand all Collapse all DANMARKS TEKNISKE UNIVERSITET Denmark EU contribution € 1 464 910,00 Address Anker engelunds vej 101 2800 Kongens lyngby See on map Region Danmark Hovedstaden Københavns omegn Activity type Higher or Secondary Education Establishments Administrative Contact Karen Bue Bitsch (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data DANONE RESEARCH SAS France EU contribution € 0,00 Address Route departementale 128 91767 Palaiseau See on map Region Ile-de-France Ile-de-France Essonne Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Patrice Lecoeuche (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data EUROPEAN MOLECULAR BIOLOGY LABORATORY Germany EU contribution € 1 434 954,15 Address Meyerhofstrasse 1 69117 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Research Organisations Administrative Contact Keith Williamson (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data INSTITUT CATALA DE LA SALUT Spain EU contribution € 417 000,00 Address Gran via de les corts catalanes 587 08007 Barcelona See on map Region Este Cataluña Barcelona Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Juan E. Feliu (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data ISTITUTO EUROPEO DI ONCOLOGIA SRL Italy EU contribution € 392 000,00 Address Via filodrammatici 10 20121 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Ilaria Foti (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data NOVO NORDISK A/S Denmark EU contribution € 295 000,00 Address Novo alle 1 2880 Bagsvaerd See on map Region Danmark Hovedstaden Københavns omegn Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Oluf Pedersen (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data SYDDANSK UNIVERSITET Participation ended Denmark EU contribution € 418 429,00 Address Campusvej 55 5230 Odense m See on map Region Danmark Syddanmark Fyn Activity type Higher or Secondary Education Establishments Administrative Contact Jens Kierkegaard (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UCB PHARMA SA Spain EU contribution € 0,00 Address Avenida de barcelona 239 08750 Molins de rei See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Ellen Caldwell (Ms.) Links Contact the organisation Opens in new window Other funding No data WAGENINGEN UNIVERSITY Netherlands EU contribution € 622 722,00 Address Droevendaalsesteeg 4 6708 PB Wageningen See on map Region Oost-Nederland Gelderland Veluwe Activity type Higher or Secondary Education Establishments Administrative Contact Willem Meindert De Vos (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data GENOME RESEARCH LIMITED United Kingdom EU contribution € 680 885,20 Address Wellcome sanger institute wellcome genome campus hinxton CB10 1SA Saffron walden See on map Region East of England East Anglia Cambridgeshire CC Activity type Research Organisations Administrative Contact Julian Parkhill (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES France EU contribution € 1 854 000,00 Address Rue leblanc 25 75015 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Jean Weissenbach (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data BEIJING INSTITUTE OF GENOMICS CHINESE ACADEMY OF SCIENCES Participation ended China EU contribution € 0,00 Address Beitucheng west road 7 100029 Beijing See on map Activity type Research Organisations Administrative Contact Huanming Yang (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data Beijing Genomics Institute at Shenzhen China EU contribution € 459 511,00 Address Beishan industrial zone 518083 Shenzhen See on map Activity type Research Organisations Administrative Contact Huanming Yang (Prof.) Links Contact the organisation Opens in new window Other funding No data KOBENHAVNS UNIVERSITET Denmark EU contribution € 1 071 571,00 Address Norregade 10 1165 Kobenhavn See on map Region Danmark Hovedstaden Byen København Activity type Higher or Secondary Education Establishments Administrative Contact Ivan Kristoffersen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data MERIEUX ALLIANCE SA France EU contribution € 0,00 Address Rue bourgelat 17 69002 Lyon See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Martine Cattelain (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
