Objective T-cell activation, whether induced by pathogens or auto-antigens, is a complex process relying on multiple layers of tightly controlled intracellular signalling modules that form an intricate network. Defects in this network can cause severe and chronic disorders such as autoimmune diseases. Although 5% of the population suffer from these diseases, only a few therapeutic treatments are available. To a large extent this is attributed to the lack of systems-level insights, which would provide concepts of how to modulate T-cell activation. The SYBILLA project groups 14 partners from 9 different EU countries, including 3 SMEs. Through a multidisciplinary effort it aims to understand at the systems’ level, how T-cells discriminate foreign from auto-antigens. Towards this goal, a transgenic mouse system will be used as a tractable physiological model. Data will be validated in human T-cells and a humanised mouse model for multiple sclerosis. SYBILLA will develop technological and mathematical tools to generate and integrate high-density quantitative data describing T-cell activation. Proteomics, transcriptomics, metabolomics, imaging and multiplexed biochemical techniques will be applied to obtain holistic maps of T-cell signalling networks and to achieve a quantitative understanding of the network and its regulation in response to different inputs. Building upon our existing network model, constant iterations will be used to develop more robust dynamic models to describe the network’s response to perturbations. This will culminate in the generation of a Virtual T-Cell, allowing computer simulation to refine the predictability of physiological and pathophysiological reactions. SYBILLA’s impact on EU biopharmaceutical competitiveness will be enormous through identification of new pharmacologic targets, optimised prediction of immunomodulatory drug efficacy, discovery of new concerted biomarkers and improvement of personalised medication for treating autoimmune diseases. Fields of science natural sciencesbiological sciencescell biologycell signalingmedical and health sciencesbasic medicineneurologymultiple sclerosismedical and health sciencesbasic medicineimmunologyautoimmune diseases Keywords TCR/CD3 auto-immune disease dynamic models multiple sclerosis signalling network Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-2.1.2-2 - Modelling of T-cell activation Call for proposal FP7-HEALTH-2007-A See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator ALBERT-LUDWIGS-UNIVERSITAET FREIBURG EU contribution € 418 100,33 Address FAHNENBERGPLATZ 79098 Freiburg Germany See on map Region Baden-Württemberg Freiburg Freiburg im Breisgau, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Wolfgang Schamel (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (21) Sort alphabetically Sort by EU Contribution Expand all Collapse all THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution € 1 156 331,00 Address WELLINGTON SQUARE UNIVERSITY OFFICES OX1 2JD Oxford See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Higher or Secondary Education Establishments Administrative Contact Martin Wilkins (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Spain EU contribution € 581 154,00 Address CALLE SERRANO 117 28006 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Administrative Contact Balbino Alarcon (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MEDIZINISCHE UNIVERSITAT INNSBRUCK Austria EU contribution € 583 375,00 Address CHRISTOPH PROBST PLATZ 1 6020 Innsbruck See on map Region Westösterreich Tirol Innsbruck Activity type Higher or Secondary Education Establishments Administrative Contact Gottfried Baier (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Switzerland EU contribution € 1 164 600,00 Address Raemistrasse 101 8092 Zuerich See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Administrative Contact Ruedi Aebersold (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG Germany EU contribution € 582 136,00 Address IM NEUENHEIMER FELD 280 69120 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Research Organisations Administrative Contact Ina Krischek (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data TURUN YLIOPISTO Finland EU contribution € 1 280 606,00 Address YLIOPISTONMAKI 20014 Turku See on map Region Manner-Suomi Etelä-Suomi Varsinais-Suomi Activity type Higher or Secondary Education Establishments Administrative Contact Eliisa Särkilahti (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS France EU contribution € 711 479,00 Address RUE MICHEL ANGE 3 75794 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Béatrice Saint-Cricq (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITATSSPITAL BASEL Switzerland EU contribution € 514 000,00 Address HEBELSTRASSE 32 4031 Basel See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Ed Palmer (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data OTTO-VON-GUERICKE-UNIVERSITAET MAGDEBURG Germany EU contribution € 544 040,00 Address UNIVERSITAETSPLATZ 2 39106 Magdeburg See on map Region Sachsen-Anhalt Sachsen-Anhalt Magdeburg, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Ingrid Anders (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FONDAZIONE HUMANITAS PER LA RICERCA Italy EU contribution € 546 000,00 Address Via Manzoni 20089 Rozzano See on map Activity type Research Organisations Administrative Contact Danilo Petroni (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MEDICEL OY Participation ended Finland EU contribution € 373 355,86 Address HAARTMANINKATU 8 00290 HELSINKI See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Risto Renkonen (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data EXBIO PRAHA AS Czechia EU contribution € 665 500,00 Address Nad Safinou II, 366 25242 VESTEC See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jolana Vosáhlová (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ACIES SAS Participation ended France EU contribution € 53 969,89 Address 69 Rue de la République 69002 LYON See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Patrick Duvarry (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Immune Disease Institute United States EU contribution No data Address HUNTINGTON AVENUE 800 MA 02115 BOSTON See on map Activity type Research Organisations Administrative Contact Stephen Carriuolo (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY Italy EU contribution No data Address PADRICIANO 99 34149 Trieste See on map Region Nord-Est Friuli-Venezia Giulia Trieste Activity type Research Organisations Administrative Contact H.S. Narayanan (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data JOSLIN DIABETES CENTER INC United States EU contribution No data Address ONE JOSLIN PLACE MA 02215 BOSTON MASSACHUSETTS See on map Activity type Other Administrative Contact Natalie Liang (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ACIES Consulting Group SAS France EU contribution € 306 797,11 Address rue de la République 69 69002 LYON See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Patrick Duvarry (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data NOVAMEN SAS Participation ended France EU contribution No data Address Rue de la République 69 69002 LYON See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Patrick Duvarry (Mr.) Links Contact the organisation Opens in new window Total cost No data TTY-SAATIO Finland EU contribution € 326 644,14 Address Korkeakoulunkatu 10 33720 Tampere See on map Activity type Higher or Secondary Education Establishments Administrative Contact Merja Fagerström (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER Spain EU contribution No data Address CALLE ROSSELLO 149 PUERTA BJS 08036 Barcelona See on map Region Este Cataluña Barcelona Activity type Other Administrative Contact Pastora Martinez Samper (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Participation ended Germany EU contribution € 1 291 911,67 Address HOFGARTENSTRASSE 8 80539 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Miriam Vitt (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
