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Understanding and fighting metastasis by modulating the tumour microenvironment through interference with the protease network

Objective

The MICROENVIMET project proposes innovative approaches for building a comprehensive understanding of the interplay between cancer cells and their microenvironment both at primary and secondary sites. The objectives are to identify molecular pathways involved in the regulation of metastatic dissemination to lung, liver, lymph node and bone. To achieve these objectives, the original experimental approach proposed is to modulate the production/activity of proteases or their inhibitors. Proteases are now recognized as key regulators of a complex network of interacting molecules that modulate the properties of cancer cells and their microenvironment. The project is intended to identify key molecular pathways underlying early steps of metastatic dissemination by interfering with the protease network and studying the impact of such experimentally manipulated microenvironment on metastasis formation. In addition to identifying key regulators of metastasis, we aim at developing blocking antibodies towards these new candidates, with efficacy for therapeutic intervention, by using the most advanced state-of-the-art technologies. The study of cancer stem cells will be integrated into current concepts that consider and attempt to explain the importance of the microenvironment during cancer progression. The 9 academic and 1 SME Participants will combine expertise in genomics, proteomics, bioinformatics, in vivo imaging, transgenic mice, mouse models of metastasis, genetic manipulation of transplantable tumour cells, computerized image analysis, virus-mediated gene transfer, phage display and production of neutralizing antibodies. This consortium will facilitate shared access to a new microRNA platform, innovative technologies, human tumour tissue banks, in vivo and in vitro models mimicking different steps of metastatic dissemination, as well as know how in tumour-host cell interplay, angiogenesis, lymphangiogenesis, cancer stem cell biology and generation of database.

Field of science

  • /natural sciences/biological sciences/cell biology
  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /medical and health sciences/medical biotechnology/genetic engineering/gene therapy
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/proteomics

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

UNIVERSITE DE LIEGE
Address
Place Du 20 Aout 7
4000 Liege
Belgium
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 599 243,20
Administrative Contact
Isabelle Halleux (Dr.)

Participants (8)

HELSINGIN YLIOPISTO
Finland
EU contribution
€ 331 176
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Katariina Vainio-Mattila (Ms.)
UNIVERSITA DEGLI STUDI DI TORINO
Italy
EU contribution
€ 261 280
Address
Via Giuseppe Verdi 8
10124 Torino
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maria Flavia Di Renzo (Prof.)
KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN
Germany
EU contribution
€ 317 920
Address
Ismaninger Strasse 22
81675 Muenchen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Achim Krüger (Prof.)
UNIVERSIDAD DE OVIEDO
Spain
EU contribution
€ 219 280
Address
Calle San Francisco 3
33003 Oviedo
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rosa Maria Corujo Quidiello (Ms.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 388 356,80
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Administrative Contact
Hélène Faradji (Dr.)
UNIVERSITAETSKLINIKUM FREIBURG
Germany
EU contribution
€ 315 708
Address
Hugstetter Strasse 49
79106 Freiburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jürgen Dreyer (Mr.)
INSTITUT JOZEF STEFAN
Slovenia
EU contribution
€ 243 325
Address
Jamova 39
1000 Ljubljana
Activity type
Research Organisations
Administrative Contact
Jadran Lenarcic (Prof.)
REGION HOVEDSTADEN
Denmark
EU contribution
€ 323 400
Address
Kongens Vaenge 2
3400 Hillerod
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Tove Ostergaard (Ms.)