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Embryonic Stem cell-based Novel Alternative Testing Strategies

Objective

"ESNATS aims at developing a novel toxicity test platform based on embryonic stem cells (ESC), especially human ESC (hESC), to accelerate drug development, reduce R&D costs and propose a powerful alternative to animal tests (3 Rs). ESNATS will address current drug-testing shortcomings: - testing takes place late in the development cycle - animal test systems bear the risk of non-prediction due to inter-species variation - non-ESC assays rely on primary cells or cells of malignant origin that are hard-to-standardise and limited in regard to quantity, homogeneity and genetic diversity - existing assay systems based on primary animal cell lines do not reliably represent the physiological situation ESNATS will develop a battery of toxicity tests using hESC lines subjected to different standardised culture protocols. Tests will cover embryoid bodies in different developmental stages and differentiated derivatives including gamete and neuronal lineages, complemented with test systems for hepatic metabolism. Predictive toxicogenomics and proteomics markers will be identified. The individual tests will be integrated into an ""all-in-one"" test system. To enable future industrial use ESNATS will prepare automating and scaling up of hESC culture. The predictivity, quality and reproducibility of ESNATS will be evaluated in a proof of concept study. ESNATS benefits are to increase safety due to better predictivity of human test systems, to reduce, refine and replace animal tests, to lower testing cost, and to support medium/high throughput testing. ESNATS objectives will be achieved in a 5 year multi-disciplinary collaboration of leading European researchers in alternative testing, toxicology, ESC research, genomics, modelling, and automation. The consortium will also include representatives from regulatory bodies, the pharmaceutical industry and ethical advisors to provide guidance to ensure rapid applicability of the developed tests systems."

Field of science

  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /social sciences/sociology/industrial relations/automation
  • /medical and health sciences/basic medicine/toxicology
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/proteomics

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

KLINIKUM DER UNIVERSITAET ZU KOELN
Address
Kerpener Strasse 62
50937 Koeln
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 825 955,59
Administrative Contact
Jutta Landvogt (Ms.)

Participants (32)

JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION
Belgium
EU contribution
€ 604 973
Address
Rue De La Loi 200
1049 Brussels
Activity type
Research Organisations
Administrative Contact
Raymond Crandon (Dr.)
UNIVERSITY OF NEWCASTLE UPON TYNE

Participation ended

United Kingdom
EU contribution
€ 261 783,16
Address
Kings Gate
NE1 7RU Newcastle Upon Tyne
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Amanda Gregory (Dr.)
UNIVERSITE DE GENEVE
Switzerland
EU contribution
€ 1 162 283
Address
Rue Du General Dufour 24
1211 Geneve
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Pierre Spierer (Prof.)
FORSCHUNGSGESELLSCHAFT FUR ARBEITSPHYSIOLOGIE UND ARBEITSSCHUTZ E.V.
Germany
EU contribution
€ 1 056 023,75
Address
Ardeystrasse 67
44139 Dortmund
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Michael Paul (Mr.)
EUROPEAN CONSENSUS PLATFORM ON 3R-ALTERNATIVES TO ANIMAL EXPERIMENTATION
Belgium
EU contribution
€ 22 760
Address
Paul Deschanel Laan 36-38
1030 Brussel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Bernward Garthoff (Dr.)
THE AUTOMATION PARTNERSHIP (CAMBRIDGE) LIMITED
United Kingdom
EU contribution
€ 172 800
Address
York Way
SG8 5WY Royston
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Alex Knell (Mr.)
OU QURETEC
Estonia
EU contribution
€ 501 400
Address
Ulikooli 6A
51003 Tartu
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jaak Vilo (Dr.)
PROTEOSYS AG
Germany
EU contribution
€ 83 757
Address
Carl Zeissstrasse 51
55129 Mainz
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Bernd Matuschek (Mr.)
UNIVERSITE DE LIEGE

Participation ended

Belgium
EU contribution
€ 50 455,70
Address
Place Du 20 Aout 7
4000 Liege
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Isabelle Halleux (Dr.)
CONSORZIO PER L'INCREMENTO ZOOTECNICO SRL

Participation ended

Italy
EU contribution
€ 69 920
Address
Via Maremmana 17 A/c
56024 San Miniato
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Gerardo Marigliano (Dr.)
Takara Bio Europe AB
Sweden
EU contribution
€ 485 595
Address
Arvid Wallgrens Backe
413 46 Göteborg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jenny Goodwin (Ms.)
CELL CURE NEUROSCIENCES LTD
Israel
EU contribution
€ 176 400
Address
Kiryat Hadassah Main Building Sixth
91121 Jerusalem
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Charles Irving (Dr.)
UNIVERSITAT KONSTANZ
Germany
EU contribution
€ 892 173
Address
Universitatsstrasse 10
78464 Konstanz
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Margit Mosbacher (Ms.)
Public Health England an Executive Agency of the Dept of Health
United Kingdom
EU contribution
€ 41 483,67
Address
Waterloo Road
SE1 8UG London
Activity type
Research Organisations
Administrative Contact
Victor Knight (Mr.)
NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO
Netherlands
EU contribution
€ 330 075
Address
Anna Van Buerenplein 1
2595 DA Den Haag
Activity type
Research Organisations
Administrative Contact
John Hoebe (Dr.)
THE UNIVERSITY OF EDINBURGH
United Kingdom
EU contribution
€ 743 670
Address
Old College, South Bridge
EH8 9YL Edinburgh
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Angela Noble (Ms.)
VRIJE UNIVERSITEIT BRUSSEL
Belgium
EU contribution
€ 636 294
Address
Pleinlaan 2
1050 Brussel
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Martina Follet (Ms.)
KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN

Participation ended

Germany
EU contribution
€ 103 439,25
Address
Ismaninger Strasse 22
81675 Muenchen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Inge Linder (Ms.)
ARTTIC
France
EU contribution
€ 712 035
Address
Rue Du Dessous Des Berges 58A
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Eric Papon (Dr.)
THE SCHOOL OF PHARMACY, UNIVERSITY OF LONDON

Participation ended

United Kingdom
EU contribution
€ 1 974,54
Address
Brunswick Square 29-39
WC1N 1AX London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maureen Boylan (Ms.)
N.V. ORGANON

Participation ended

Netherlands
Address
Kloosterstraat 6
5349 AB Oss
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Thuijs De Boer (Dr.)
LAKEMEDELSVERKET
Sweden
Address
Dag Hammarskjolds Vag 42
75103 Uppsala
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Ira Palminger Hallén (Dr.)
H. LUNDBECK AS
Denmark
Address
Ottiliavej 7-9
2500 Valby
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Nina Ostenfeldt (Dr.)
IN VITRO TESTING INDUSTRIAL PLATFORM
Spain
Address
Avenida De La Industria 52
28760 Tres Cantos Madrid
Activity type
Other
Administrative Contact
Joan-Albert Vericat (Dr.)
BUNDESINSTITUT FUER RISIKOBEWERTUNG
Germany
Address
Max Dohrn Strasse 8-10
10589 Berlin
Activity type
Research Organisations
Administrative Contact
Karin Schlesier (Dr.)
EDINETHICS LIMITED
United Kingdom
EU contribution
€ 36 000
Address
Dundonald Street 11 6
EH3 6RZ Edinburgh
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Donald Malcolm Bruce (Dr.)
GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER
Germany
EU contribution
€ 222 695
Address
Welfengarten 1
30167 Hannover
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ludwig Hothorn (Prof.)
F. HOFFMANN-LA ROCHE AG
Switzerland
Address
Grenzacherstrasse 124
4070 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Nicole Clemann (Dr.)
AVANTEA srl
Italy
EU contribution
€ 397 328,80
Address
Via Cabrini 12
26100 Cremona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Cesare Galli (Prof.)
BRUNEL UNIVERSITY LONDON
United Kingdom
EU contribution
€ 148 025,46
Address
Kingston Lane
UB8 3PH Uxbridge
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Teresa Waller (Ms.)
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
EU contribution
€ 46 560,75
Address
Geschwister-scholl-platz
72074 Tuebingen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Andreas Nuessler (Prof.)
Department of Health
United Kingdom
EU contribution
€ 109 716,33
Address
Quarry House, Quarry Hill
LS2 7UE Leeds
Activity type
Research Organisations
Administrative Contact
Amanda King (Ms.)