Embryonic Stem cell-based Novel Alternative Testing Strategies

Project Information

ESNATS

Grant agreement ID: 201619

Project closed

Start date 1 April 2008

End date 30 September 2013

Funded under

• Specific Programme "Cooperation": Health

Total cost € 15 592 219,98

EU contribution € 11 895 577,00

Coordinated by

KLINIKUM DER UNIVERSITAET ZU KOELN
Germany

Objective

"ESNATS aims at developing a novel toxicity test platform based on embryonic stem cells (ESC), especially human ESC (hESC), to accelerate drug development, reduce R&D costs and propose a powerful alternative to animal tests (3 Rs). ESNATS will address current drug-testing shortcomings: - testing takes place late in the development cycle - animal test systems bear the risk of non-prediction due to inter-species variation - non-ESC assays rely on primary cells or cells of malignant origin that are hard-to-standardise and limited in regard to quantity, homogeneity and genetic diversity - existing assay systems based on primary animal cell lines do not reliably represent the physiological situation ESNATS will develop a battery of toxicity tests using hESC lines subjected to different standardised culture protocols. Tests will cover embryoid bodies in different developmental stages and differentiated derivatives including gamete and neuronal lineages, complemented with test systems for hepatic metabolism. Predictive toxicogenomics and proteomics markers will be identified. The individual tests will be integrated into an ""all-in-one"" test system. To enable future industrial use ESNATS will prepare automating and scaling up of hESC culture. The predictivity, quality and reproducibility of ESNATS will be evaluated in a proof of concept study. ESNATS benefits are to increase safety due to better predictivity of human test systems, to reduce, refine and replace animal tests, to lower testing cost, and to support medium/high throughput testing. ESNATS objectives will be achieved in a 5 year multi-disciplinary collaboration of leading European researchers in alternative testing, toxicology, ESC research, genomics, modelling, and automation. The consortium will also include representatives from regulatory bodies, the pharmaceutical industry and ethical advisors to provide guidance to ensure rapid applicability of the developed tests systems."

Fields of science

• medical and health sciences › basic medicine › pharmacology and pharmacy › drug discovery
• natural sciences › biological sciences › biochemistry › biomolecules › proteins › proteomics
• social sciences › sociology › industrial relations › automation
• medical and health sciences › medical biotechnology › cells technologies › stem cells
• medical and health sciences › basic medicine › toxicology

Keywords

• CNS toxicity
• alternative testing
• cocktail effects
• embryonic stem cells
• hepatic metabolism
• reproductive toxicity
• toxicogenomics

Programme(s)

• FP7-HEALTH - Specific Programme "Cooperation": Health

Topic(s)

• HEALTH-2007-1.3-1 - Novel alternative testing strategies for use in pharmaceutical discovery and development

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

KLINIKUM DER UNIVERSITAET ZU KOELN

• EU contribution: € 2 825 955,59
• Address: Kerpener Strasse 62 ; 50937 Koeln ; Germany
• Region: Nordrhein-Westfalen › Köln › Köln, Kreisfreie Stadt
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Jutta Landvogt (Ms.)
• Total cost: No data

Participants (32)

JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION

Belgium

• EU contribution: € 604 973,00
• Address: Rue de la Loi 200 ; 1049 Bruxelles / Brussel
• Region: Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest › Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest › Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
• Activity type: Research Organisations
• Administrative Contact: Raymond Crandon (Dr.)
• Total cost: No data

UNIVERSITY OF NEWCASTLE UPON TYNE

Participation ended

United Kingdom

• EU contribution: € 261 783,16
• Address: KINGS GATE ; NE1 7RU Newcastle Upon Tyne
• Region: North East (England) › Northumberland and Tyne and Wear › Tyneside
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Amanda Gregory (Dr.)
• Total cost: No data

UNIVERSITE DE GENEVE

Switzerland

• EU contribution: € 1 162 283,00
• Address: RUE DU GENERAL DUFOUR 24 ; 1211 Geneve
• Region: Schweiz/Suisse/Svizzera › Région lémanique › Genève
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Pierre Spierer (Prof.)
• Total cost: No data

FORSCHUNGSGESELLSCHAFT FUR ARBEITSPHYSIOLOGIE UND ARBEITSSCHUTZ EV

Germany

• EU contribution: € 1 056 023,75
• Address: ARDEYSTRASSE 67 ; 44139 Dortmund
• Region: Nordrhein-Westfalen › Arnsberg › Dortmund, Kreisfreie Stadt
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Michael Paul (Mr.)
• Total cost: No data

EUROPEAN CONSENSUS PLATFORM ON 3R-ALTERNATIVES TO ANIMAL EXPERIMENTATION

Belgium

• EU contribution: € 22 760,00
• Address: Paul Deschanel Laan 36-38 ; 1030 BRUSSEL
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Bernward Garthoff (Dr.)
• Total cost: No data

THE AUTOMATION PARTNERSHIP (CAMBRIDGE) LIMITED

United Kingdom

• EU contribution: € 172 800,00
• Address: YORK WAY ; SG8 5WY ROYSTON
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Alex Knell (Mr.)
• Total cost: No data

OU QURETEC

Estonia

• EU contribution: € 501 400,00
• Address: ULIKOOLI 6A ; 51003 Tartu
• Region: Eesti › Eesti › Lõuna-Eesti
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Jaak Vilo (Dr.)
• Total cost: No data

PROTEOSYS AG

Germany

• EU contribution: € 83 757,00
• Address: CARL ZEISSSTRASSE 51 ; 55129 MAINZ
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Bernd Matuschek (Mr.)
• Total cost: No data

UNIVERSITE DE LIEGE

Participation ended

Belgium

• EU contribution: € 50 455,70
• Address: PLACE DU 20 AOUT 7 ; 4000 Liege
• Region: Région wallonne › Prov. Liège › Arr. Liège
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Isabelle Halleux (Dr.)
• Total cost: No data

CONSORZIO PER L'INCREMENTO ZOOTECNICO SRL

Participation ended

Italy

• EU contribution: € 69 920,00
• Address: VIA MAREMMANA 17 A/C ; 56024 SAN MINIATO
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Gerardo Marigliano (Dr.)
• Total cost: No data

Takara Bio Europe AB

Sweden

• EU contribution: € 485 595,00
• Address: Arvid Wallgrens backe ; 413 46 Göteborg
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Jenny Goodwin (Ms.)
• Total cost: No data

CELL CURE NEUROSCIENCES LTD

Israel

• EU contribution: € 176 400,00
• Address: KIRYAT HADASSAH MAIN BUILDING SIXTH ; 91121 JERUSALEM
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Charles Irving (Dr.)
• Total cost: No data

UNIVERSITAT KONSTANZ

Germany

• EU contribution: € 892 173,00
• Address: UNIVERSITATSSTRASSE 10 ; 78464 Konstanz
• Region: Baden-Württemberg › Freiburg › Konstanz
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Margit Mosbacher (Ms.)
• Total cost: No data

HEALTH PROTECTION AGENCY HPA

United Kingdom

• EU contribution: € 41 483,67
• Address: BUCKINGHAM PALACE ROAD 151 ; SW1W 9SZ London
• Activity type: Research Organisations
• Administrative Contact: Victor Knight (Mr.)
• Total cost: No data

NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO

Netherlands

• EU contribution: € 330 075,00
• Address: ANNA VAN BUERENPLEIN 1 ; 2595 DA Den Haag
• Region: West-Nederland › Zuid-Holland › Agglomeratie ’s-Gravenhage
• Activity type: Research Organisations
• Administrative Contact: John Hoebe (Dr.)
• Total cost: No data

THE UNIVERSITY OF EDINBURGH

United Kingdom

• EU contribution: € 743 670,00
• Address: OLD COLLEGE, SOUTH BRIDGE ; EH8 9YL Edinburgh
• Region: Scotland › Eastern Scotland › Edinburgh
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Angela Noble (Ms.)
• Total cost: No data

VRIJE UNIVERSITEIT BRUSSEL

Belgium

• EU contribution: € 636 294,00
• Address: PLEINLAAN 2 ; 1050 Bruxelles / Brussel
• Region: Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest › Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest › Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Martina Follet (Ms.)
• Total cost: No data

KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN

Participation ended

Germany

• EU contribution: € 103 439,25
• Address: ISMANINGER STRASSE 22 ; 81675 Muenchen
• Region: Bayern › Oberbayern › München, Kreisfreie Stadt
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Inge Linder (Ms.)
• Total cost: No data

ARTTIC

France

• EU contribution: € 712 035,00
• Address: 39 RUE DES MATHURINS ; 75008 Paris
• Region: Ile-de-France › Ile-de-France › Paris
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Eric Papon (Dr.)
• Total cost: No data

THE SCHOOL OF PHARMACY, UNIVERSITY OF LONDON

Participation ended

United Kingdom

• EU contribution: € 1 974,54
• Address: Brunswick Square 29-39 ; WC1N 1AX LONDON
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Maureen Boylan (Ms.)
• Total cost: No data

N.V. ORGANON

Participation ended

Netherlands

• EU contribution: No data
• Address: KLOOSTERSTRAAT 6 ; 5349 AB OSS
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Thuijs De Boer (Dr.)
• Total cost: No data

LAKEMEDELSVERKET

Sweden

• EU contribution: No data
• Address: DAG HAMMARSKJOLDS VAG 42 ; 75103 Uppsala
• Region: Östra Sverige › Östra Mellansverige › Uppsala län
• Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
• Administrative Contact: Ira Palminger Hallén (Dr.)
• Total cost: No data

H. LUNDBECK AS

Denmark

• EU contribution: No data
• Address: OTTILIAVEJ 7-9 ; 2500 Valby
• Region: Danmark › Hovedstaden › Byen København
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Nina Ostenfeldt (Dr.)
• Total cost: No data

IN VITRO TESTING INDUSTRIAL PLATFORM

Spain

• EU contribution: No data
• Address: AVENIDA DE LA INDUSTRIA 52 ; 28760 TRES CANTOS MADRID
• Activity type: Other
• Administrative Contact: Joan-Albert Vericat (Dr.)
• Total cost: No data

BUNDESINSTITUT FUER RISIKOBEWERTUNG

Germany

• EU contribution: No data
• Address: MAX DOHRN STRASSE 8-10 ; 10589 Berlin
• Region: Berlin › Berlin › Berlin
• Activity type: Research Organisations
• Administrative Contact: Karin Schlesier (Dr.)
• Total cost: No data

EDINETHICS LIMITED

United Kingdom

• EU contribution: € 36 000,00
• Address: 1 PEINSORAIG, UIG VIEW HILL ; IV51 9YD ISLE OF SKYE
• Region: Scotland › Highlands and Islands › Lochaber, Skye & Lochalsh, Arran & Cumbrae and Argyll & Bute
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Donald Malcolm Bruce (Dr.)
• Total cost: No data

GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER

Germany

• EU contribution: € 222 695,00
• Address: WELFENGARTEN 1 ; 30167 Hannover
• Region: Niedersachsen › Hannover › Region Hannover
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Ludwig Hothorn (Prof.)
• Total cost: No data

F. HOFFMANN-LA ROCHE AG

Switzerland

• EU contribution: No data
• Address: GRENZACHERSTRASSE 124 ; 4070 Basel
• Region: Schweiz/Suisse/Svizzera › Nordwestschweiz › Basel-Stadt
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Nicole Clemann (Dr.)
• Total cost: No data

AVANTEA SRL

Italy

• EU contribution: € 397 328,80
• Address: VIA PORCELLASCO 7 F ; 26100 CREMONA
• Region: Nord-Ovest › Lombardia › Cremona
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Cesare Galli (Prof.)
• Total cost: No data

BRUNEL UNIVERSITY LONDON

United Kingdom

• EU contribution: € 148 025,46
• Address: KINGSTON LANE ; UB8 3PH Uxbridge
• Region: London › Outer London — West and North West › Harrow and Hillingdon
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Teresa Waller (Ms.)
• Total cost: No data

EBERHARD KARLS UNIVERSITAET TUEBINGEN

Germany

• EU contribution: € 46 560,75
• Address: GESCHWISTER-SCHOLL-PLATZ ; 72074 Tuebingen
• Region: Baden-Württemberg › Tübingen › Tübingen, Landkreis
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Andreas Nuessler (Prof.)
• Total cost: No data

Department of Health

United Kingdom

• EU contribution: € 109 716,33
• Address: Quarry House, Quarry Hill ; LS2 7UE Leeds
• Region: Yorkshire and the Humber › West Yorkshire › Leeds
• Activity type: Research Organisations
• Administrative Contact: Amanda King (Ms.)
• Total cost: No data