Objective "ESNATS aims at developing a novel toxicity test platform based on embryonic stem cells (ESC), especially human ESC (hESC), to accelerate drug development, reduce R&D costs and propose a powerful alternative to animal tests (3 Rs). ESNATS will address current drug-testing shortcomings: - testing takes place late in the development cycle - animal test systems bear the risk of non-prediction due to inter-species variation - non-ESC assays rely on primary cells or cells of malignant origin that are hard-to-standardise and limited in regard to quantity, homogeneity and genetic diversity - existing assay systems based on primary animal cell lines do not reliably represent the physiological situation ESNATS will develop a battery of toxicity tests using hESC lines subjected to different standardised culture protocols. Tests will cover embryoid bodies in different developmental stages and differentiated derivatives including gamete and neuronal lineages, complemented with test systems for hepatic metabolism. Predictive toxicogenomics and proteomics markers will be identified. The individual tests will be integrated into an ""all-in-one"" test system. To enable future industrial use ESNATS will prepare automating and scaling up of hESC culture. The predictivity, quality and reproducibility of ESNATS will be evaluated in a proof of concept study. ESNATS benefits are to increase safety due to better predictivity of human test systems, to reduce, refine and replace animal tests, to lower testing cost, and to support medium/high throughput testing. ESNATS objectives will be achieved in a 5 year multi-disciplinary collaboration of leading European researchers in alternative testing, toxicology, ESC research, genomics, modelling, and automation. The consortium will also include representatives from regulatory bodies, the pharmaceutical industry and ethical advisors to provide guidance to ensure rapid applicability of the developed tests systems." Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicssocial sciencessociologyindustrial relationsautomationmedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesbasic medicinetoxicology Keywords CNS toxicity alternative testing cocktail effects embryonic stem cells hepatic metabolism reproductive toxicity toxicogenomics Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-1.3-1 - Novel alternative testing strategies for use in pharmaceutical discovery and development Call for proposal FP7-HEALTH-2007-A See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator KLINIKUM DER UNIVERSITAET ZU KOELN Address Kerpener strasse 62 50937 Koeln Germany See on map Region Nordrhein-Westfalen Köln Köln, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Jutta Landvogt (Ms.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 2 825 955,59 Participants (32) Sort alphabetically Sort by EU Contribution Expand all Collapse all JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION Belgium EU contribution € 604 973,00 Address Rue de la loi 200 1049 Bruxelles / brussel See on map Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Activity type Research Organisations Administrative Contact Raymond Crandon (Dr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITY OF NEWCASTLE UPON TYNE Participation ended United Kingdom EU contribution € 261 783,16 Address Kings gate NE1 7RU Newcastle upon tyne See on map Region North East (England) Northumberland and Tyne and Wear Tyneside Activity type Higher or Secondary Education Establishments Administrative Contact Amanda Gregory (Dr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITE DE GENEVE Switzerland EU contribution € 1 162 283,00 Address Rue du general dufour 24 1211 Geneve See on map Region Schweiz/Suisse/Svizzera Région lémanique Genève Activity type Higher or Secondary Education Establishments Administrative Contact Pierre Spierer (Prof.) Links Contact the organisation Opens in new window Website Opens in new window FORSCHUNGSGESELLSCHAFT FUR ARBEITSPHYSIOLOGIE UND ARBEITSSCHUTZ EV Germany EU contribution € 1 056 023,75 Address Ardeystrasse 67 44139 Dortmund See on map Region Nordrhein-Westfalen Arnsberg Dortmund, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Michael Paul (Mr.) Links Contact the organisation Opens in new window Website Opens in new window EUROPEAN CONSENSUS PLATFORM ON 3R-ALTERNATIVES TO ANIMAL EXPERIMENTATION Belgium EU contribution € 22 760,00 Address Paul deschanel laan 36-38 1030 Brussel See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Bernward Garthoff (Dr.) Links Contact the organisation Opens in new window Website Opens in new window THE AUTOMATION PARTNERSHIP (CAMBRIDGE) LIMITED United Kingdom EU contribution € 172 800,00 Address York way SG8 5WY Royston See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Alex Knell (Mr.) Links Contact the organisation Opens in new window Website Opens in new window OU QURETEC Estonia EU contribution € 501 400,00 Address Ulikooli 6a 51003 Tartu See on map Region Eesti Eesti Lõuna-Eesti Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jaak Vilo (Dr.) Links Contact the organisation Opens in new window PROTEOSYS AG Germany EU contribution € 83 757,00 Address Carl zeissstrasse 51 55129 Mainz See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Bernd Matuschek (Mr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITE DE LIEGE Participation ended Belgium EU contribution € 50 455,70 Address Place du 20 aout 7 4000 Liege See on map Region Région wallonne Prov. Liège Arr. Liège Activity type Higher or Secondary Education Establishments Administrative Contact Isabelle Halleux (Dr.) Links Contact the organisation Opens in new window Website Opens in new window CONSORZIO PER L'INCREMENTO ZOOTECNICO SRL Participation ended Italy EU contribution € 69 920,00 Address Via maremmana 17 a/c 56024 San miniato See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Gerardo Marigliano (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Takara Bio Europe AB Sweden EU contribution € 485 595,00 Address Arvid wallgrens backe 413 46 Göteborg See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jenny Goodwin (Ms.) Links Contact the organisation Opens in new window Website Opens in new window CELL CURE NEUROSCIENCES LTD Israel EU contribution € 176 400,00 Address Kiryat hadassah main building sixth 91121 Jerusalem See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Charles Irving (Dr.) Links Contact the organisation Opens in new window UNIVERSITAT KONSTANZ Germany EU contribution € 892 173,00 Address Universitatsstrasse 10 78464 Konstanz See on map Region Baden-Württemberg Freiburg Konstanz Activity type Higher or Secondary Education Establishments Administrative Contact Margit Mosbacher (Ms.) Links Contact the organisation Opens in new window Website Opens in new window HEALTH PROTECTION AGENCY HPA United Kingdom EU contribution € 41 483,67 Address Buckingham palace road 151 SW1W 9SZ London See on map Activity type Research Organisations Administrative Contact Victor Knight (Mr.) Links Contact the organisation Opens in new window Website Opens in new window NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO Netherlands EU contribution € 330 075,00 Address Anna van buerenplein 1 2595 DA Den haag See on map Region West-Nederland Zuid-Holland Agglomeratie ’s-Gravenhage Activity type Research Organisations Administrative Contact John Hoebe (Dr.) Links Contact the organisation Opens in new window Website Opens in new window THE UNIVERSITY OF EDINBURGH United Kingdom EU contribution € 743 670,00 Address Old college, south bridge EH8 9YL Edinburgh See on map Region Scotland Eastern Scotland Edinburgh Activity type Higher or Secondary Education Establishments Administrative Contact Angela Noble (Ms.) Links Contact the organisation Opens in new window Website Opens in new window VRIJE UNIVERSITEIT BRUSSEL Belgium EU contribution € 636 294,00 Address Pleinlaan 2 1050 Bruxelles / brussel See on map Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Activity type Higher or Secondary Education Establishments Administrative Contact Martina Follet (Ms.) Links Contact the organisation Opens in new window Website Opens in new window KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN Participation ended Germany EU contribution € 103 439,25 Address Ismaninger strasse 22 81675 Muenchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Inge Linder (Ms.) Links Contact the organisation Opens in new window Website Opens in new window ARTTIC France EU contribution € 712 035,00 Address 39 rue des mathurins 75008 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Eric Papon (Dr.) Links Contact the organisation Opens in new window Website Opens in new window THE SCHOOL OF PHARMACY, UNIVERSITY OF LONDON Participation ended United Kingdom EU contribution € 1 974,54 Address Brunswick square 29-39 WC1N 1AX London See on map Activity type Higher or Secondary Education Establishments Administrative Contact Maureen Boylan (Ms.) Links Contact the organisation Opens in new window Website Opens in new window N.V. ORGANON Participation ended Netherlands EU contribution € 0,00 Address Kloosterstraat 6 5349 AB Oss See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Thuijs De Boer (Dr.) Links Contact the organisation Opens in new window Website Opens in new window LAKEMEDELSVERKET Sweden EU contribution € 0,00 Address Dag hammarskjolds vag 42 75103 Uppsala See on map Region Östra Sverige Östra Mellansverige Uppsala län Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Ira Palminger Hallén (Dr.) Links Contact the organisation Opens in new window Website Opens in new window H. LUNDBECK AS Denmark EU contribution € 0,00 Address Ottiliavej 7-9 2500 Valby See on map Region Danmark Hovedstaden Byen København Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Nina Ostenfeldt (Dr.) Links Contact the organisation Opens in new window Website Opens in new window IN VITRO TESTING INDUSTRIAL PLATFORM Spain EU contribution € 0,00 Address Avenida de la industria 52 28760 Tres cantos madrid See on map Activity type Other Administrative Contact Joan-Albert Vericat (Dr.) Links Contact the organisation Opens in new window Website Opens in new window BUNDESINSTITUT FUER RISIKOBEWERTUNG Germany EU contribution € 0,00 Address Max dohrn strasse 8-10 10589 Berlin See on map Region Berlin Berlin Berlin Activity type Research Organisations Administrative Contact Karin Schlesier (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EDINETHICS LIMITED United Kingdom EU contribution € 36 000,00 Address 1 peinsoraig, uig view hill IV51 9YD Isle of skye See on map Region Scotland Highlands and Islands Lochaber, Skye & Lochalsh, Arran & Cumbrae and Argyll & Bute Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Donald Malcolm Bruce (Dr.) Links Contact the organisation Opens in new window Website Opens in new window GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER Germany EU contribution € 222 695,00 Address Welfengarten 1 30167 Hannover See on map Region Niedersachsen Hannover Region Hannover Activity type Higher or Secondary Education Establishments Administrative Contact Ludwig Hothorn (Prof.) Links Contact the organisation Opens in new window Website Opens in new window F. HOFFMANN-LA ROCHE AG Switzerland EU contribution € 0,00 Address Grenzacherstrasse 124 4070 Basel See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Nicole Clemann (Dr.) Links Contact the organisation Opens in new window Website Opens in new window AVANTEA srl Italy EU contribution € 397 328,80 Address Via cabrini 12 26100 Cremona See on map Region Nord-Ovest Lombardia Cremona Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Cesare Galli (Prof.) Links Contact the organisation Opens in new window Website Opens in new window BRUNEL UNIVERSITY LONDON United Kingdom EU contribution € 148 025,46 Address Kingston lane UB8 3PH Uxbridge See on map Region London Outer London — West and North West Harrow and Hillingdon Activity type Higher or Secondary Education Establishments Administrative Contact Teresa Waller (Ms.) Links Contact the organisation Opens in new window Website Opens in new window EBERHARD KARLS UNIVERSITAET TUEBINGEN Germany EU contribution € 46 560,75 Address Geschwister-scholl-platz 72074 Tuebingen See on map Region Baden-Württemberg Tübingen Tübingen, Landkreis Activity type Higher or Secondary Education Establishments Administrative Contact Andreas Nuessler (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Department of Health United Kingdom EU contribution € 109 716,33 Address Quarry house, quarry hill LS2 7UE Leeds See on map Region Yorkshire and the Humber West Yorkshire Leeds Activity type Research Organisations Administrative Contact Amanda King (Ms.) Links Contact the organisation Opens in new window Website Opens in new window
