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European Network for Cell Imaging and Tracking Expertise

Objective

Cell therapy can be defined as the transplantation of living cells for the treatment of medical disorders. Three different principles underlie the increasing interest in cell therapy. 1. Transplanted cells used as an “active drug” 2. Transplanted cells used to replace damaged and degenerated tissue. 3. Cells used as a drug delivery vehicle. Promising results have been obtained in pre-clinical and clinical studies, however, success rates have been variable and clinical benefits have been limited. A major issue is the fact that the mechanisms by which cell therapy works in the different disease areas, are still poorly understood. The ability to non-invasively monitor the fate and modes of action of transplanted cells over time is mandatory. The development of relevant imaging tools will lead to a better understanding of how cell therapy works, the possibility of response monitoring in patients, and sufficient safety of the treatment.. ENCITE will provide tools to allow this by developing; • New imaging methods to improve the spatio-temporal tracking of labelled cells • Dual- and multimodality imaging procedures to cross-validate each individual approach • New contrast agents and procedures that will improve the sensitivity and specificity of cellular labelling • Combining of molecular biology for the generation of molecular and cellular imaging reporters with multimodal imaging techniques • Novel cell and animal reporter systems detecting the location and function of individual cells and small cell subsets within the target organ • Cellular labelling that does not interfere with cellular functions and therapeutic efficacy • Methods for quantitative assessment to generate reliable biomarkers of the cell fate and therapeutic effects • Cell homing for therapeutic delivery to target organs The tools and methodologies developed will be validated in 5 key disease areas; Neurological, Cardiovascular, Musculoskeletal, Diabetes and Cancer.

Field of science

  • /medical and health sciences/clinical medicine/transplantation
  • /natural sciences/biological sciences/molecular biology
  • /medical and health sciences/clinical medicine/endocrinology/diabetes
  • /medical and health sciences/clinical medicine/oncology/cancer

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

EIBIR GEMEINNUTZIGE GMBH ZUR FORDERUNG DER ERFORSCHUNG DER BIOMEDIZINISCHEN BILDGEBUNG
Address
Am Gestade 1
1010 Wien
Austria
Activity type
Research Organisations
EU contribution
€ 1 263 323
Administrative Contact
Monika Hierath (Ms.)

Participants (29)

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 638 700
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Linda A Everse (Dr.)
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 532 000
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Silke Blohm (Ms.)
WEIZMANN INSTITUTE OF SCIENCE
Israel
EU contribution
€ 608 480
Address
Herzl Street 234
7610001 Rehovot
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Talia Tzahor (Ms.)
Klinik Max Planck Institut für Psychiatrie
Germany
EU contribution
€ 694 448
Address
Hofgartenstrasse 8
80539 Muenchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jürgen Baaske (Mr.)
TEL AVIV UNIVERSITY
Israel
EU contribution
€ 339 999
Address
Ramat Aviv
69978 Tel Aviv
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lea Pais (Ms.)
UNIVERSITA DEGLI STUDI DI TORINO
Italy
EU contribution
€ 596 000
Address
Via Giuseppe Verdi 8
10124 Torino
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Alessandro De Filippo (Mr.)
Institut klinické a experimentální mediciny
Czechia
EU contribution
€ 493 968
Address
Videnska 1958/9
14021 Prague 4
Activity type
Research Organisations
Administrative Contact
Tomas Linhart (Dr.)
UNIVERSITAETSKLINIKUM FREIBURG
Germany
EU contribution
€ 476 000
Address
Hugstetter Strasse 49
79106 Freiburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gerhard Henninger (Mr.)
UNIVERSITE DE MONS
Belgium
EU contribution
€ 533 600
Address
Place Du Parc 20
7000 Mons
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Robert Muller (Prof.)
UNIVERSITE PARIS DESCARTES
France
EU contribution
€ 490 400
Address
Rue De L Ecole De Medecine 12
75270 Paris Cedex 06
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Olivier Clement (Pr Dr)
FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG

Participation ended

Germany
EU contribution
€ 367 190
Address
Schlossplatz 4
91054 Erlangen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ulrich Winderl (Mr.)
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 489 600
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Daan Katchaki (Dr.)
UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA
Italy
EU contribution
€ 485 604
Address
Piazza Dell'ateneo Nuovo 1
20126 Milano
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anastasia Sguera (Dr.)
STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
EU contribution
€ 1 132 080
Address
Geert Grooteplein Noord 9
6525 EZ Nijmegen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Wim Bruinenberg (Mr.)
FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA
Spain
EU contribution
€ 263 620
Address
Avenida De Pio Xii 55
31008 Pamplona
Activity type
Research Organisations
Administrative Contact
Andrew Solomon (Dr.)
INSTITUT CURIE
France
EU contribution
€ 469 600
Address
Rue D'ulm 26
75231 Paris
Activity type
Research Organisations
Administrative Contact
Corrine Cumin (Ms.)
BIOSPACE LAB
France
EU contribution
€ 226 300
Address
11 Rue De Chenival
95690 Nesles-la-vallee
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Pierre-Alix Dancer (Mr.)
MEDRES-MEDICAL RESEARCH GMBH
Germany
EU contribution
€ 215 500
Address
Gleueler Strasse 50
50931 Koln
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Stefan Wecker (Mr.)
CAGE CHEMICALS SRL
Italy
EU contribution
€ 207 400
Address
Via Bovio 6
28100 Novara
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Camilla Cavallotti (Dr.)
UNIVERSIDAD DE NAVARRA
Spain
EU contribution
€ 220 000
Address
Campus Universitario Edificio Central
31080 Pamplona
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Cristina Patsouris (Dr.)
THE HEBREW UNIVERSITY OF JERUSALEM
Israel
EU contribution
€ 158 400
Address
Edmond J Safra Campus Givat Ram
91904 Jerusalem
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jane Turner (Ms.)
Westfälische Wilhelms-Universität Münster
Germany
EU contribution
€ 169 861
Address
Schlossplatz 2
48149 Muenster
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Katharina Steinberg (Dr.)
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 153 100
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Elke Lammertyn (Dr.)
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 196 687
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Keith Cann (Mr.)
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 147 975
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
Administrative Contact
Carlos Manuel Abad Ruiz (Mr.)
Consorci Institut Catala de Ciències Cardiovasculars
Spain
EU contribution
€ 149 250
Address
Av. Santantoni M. Claret
08025 Barcelona
Activity type
Research Organisations
Administrative Contact
Jaume Guasch (Mr.)
VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG
Netherlands
EU contribution
€ 20 475
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
N.M. Bock (Ms.)
UNIVERSITATSSPITAL BASEL
Switzerland
EU contribution
€ 155 975
Address
Hebelstrasse 32
4031 Basel
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Klaus Scheffler (Prof.)
UNIVERSITATSKLINIKUM ERLANGEN
Germany
EU contribution
€ 102 410
Address
Maximiliansplatz 2
91054 Erlangen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Katrin Faber (Dr.)