Objective Cell therapy can be defined as the transplantation of living cells for the treatment of medical disorders. Three different principles underlie the increasing interest in cell therapy. 1. Transplanted cells used as an “active drug” 2. Transplanted cells used to replace damaged and degenerated tissue. 3. Cells used as a drug delivery vehicle. Promising results have been obtained in pre-clinical and clinical studies, however, success rates have been variable and clinical benefits have been limited. A major issue is the fact that the mechanisms by which cell therapy works in the different disease areas, are still poorly understood. The ability to non-invasively monitor the fate and modes of action of transplanted cells over time is mandatory. The development of relevant imaging tools will lead to a better understanding of how cell therapy works, the possibility of response monitoring in patients, and sufficient safety of the treatment.. ENCITE will provide tools to allow this by developing; • New imaging methods to improve the spatio-temporal tracking of labelled cells • Dual- and multimodality imaging procedures to cross-validate each individual approach • New contrast agents and procedures that will improve the sensitivity and specificity of cellular labelling • Combining of molecular biology for the generation of molecular and cellular imaging reporters with multimodal imaging techniques • Novel cell and animal reporter systems detecting the location and function of individual cells and small cell subsets within the target organ • Cellular labelling that does not interfere with cellular functions and therapeutic efficacy • Methods for quantitative assessment to generate reliable biomarkers of the cell fate and therapeutic effects • Cell homing for therapeutic delivery to target organs The tools and methodologies developed will be validated in 5 key disease areas; Neurological, Cardiovascular, Musculoskeletal, Diabetes and Cancer. Fields of science engineering and technologymedical engineeringdiagnostic imagingmedical and health sciencesmedical biotechnologycells technologiesnatural sciencesbiological sciencesmolecular biology Keywords Cancer Cardiovascular Cellular labelling Diabetes Musculoskeletal Neurological molecular biology multimodality imaging reporter systems tracking Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-1.2-4 - In vivo image-guidance for cell therapy Call for proposal FP7-HEALTH-2007-A See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator EIBIR GEMEINNUTZIGE GMBH ZUR FORDERUNG DER ERFORSCHUNG DER BIOMEDIZINISCHEN BILDGEBUNG Address Am gestade 1 1010 Wien Austria See on map Region Ostösterreich Wien Wien Activity type Research Organisations Administrative Contact Monika Hierath (Ms.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 1 263 323,00 Participants (29) Sort alphabetically Sort by EU Contribution Expand all Collapse all ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Netherlands EU contribution € 638 700,00 Address Dr molewaterplein 40 3015 GD Rotterdam See on map Region West-Nederland Zuid-Holland Groot-Rijnmond Activity type Higher or Secondary Education Establishments Administrative Contact Linda A Everse (Dr.) Links Contact the organisation Opens in new window Website Opens in new window KING'S COLLEGE LONDON United Kingdom EU contribution € 532 000,00 Address Strand WC2R 2LS London See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Administrative Contact Silke Blohm (Ms.) Links Contact the organisation Opens in new window Website Opens in new window WEIZMANN INSTITUTE OF SCIENCE Israel EU contribution € 608 480,00 Address Herzl street 234 7610001 Rehovot See on map Activity type Higher or Secondary Education Establishments Administrative Contact Talia Tzahor (Ms.) Links Contact the organisation Opens in new window Website Opens in new window MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Germany EU contribution € 694 448,00 Address Hofgartenstrasse 8 80539 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Jürgen Baaske (Mr.) Links Contact the organisation Opens in new window Website Opens in new window TEL AVIV UNIVERSITY Israel EU contribution € 339 999,00 Address Ramat aviv 69978 Tel aviv See on map Activity type Higher or Secondary Education Establishments Administrative Contact Lea Pais (Ms.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITA DEGLI STUDI DI TORINO Italy EU contribution € 596 000,00 Address Via giuseppe verdi 8 10124 Torino See on map Region Nord-Ovest Piemonte Torino Activity type Higher or Secondary Education Establishments Administrative Contact Alessandro De Filippo (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Institut klinické a experimentální mediciny Czechia EU contribution € 493 968,00 Address Videnska 1958/9 14021 Prague 4 See on map Region Česko Praha Hlavní město Praha Activity type Research Organisations Administrative Contact Tomas Linhart (Dr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITAETSKLINIKUM FREIBURG Germany EU contribution € 476 000,00 Address Hugstetter strasse 49 79106 Freiburg See on map Region Baden-Württemberg Freiburg Freiburg im Breisgau, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Gerhard Henninger (Mr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITE DE MONS Belgium EU contribution € 533 600,00 Address Place du parc 20 7000 Mons See on map Region Région wallonne Prov. 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Mons Activity type Higher or Secondary Education Establishments Administrative Contact Robert Muller (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Université Paris Descartes France EU contribution € 490 400,00 Address Rue de l'ecole de médecine 75270 cedex 06 Paris See on map Activity type Higher or Secondary Education Establishments Administrative Contact Olivier Clement (Pr Dr) Links Contact the organisation Opens in new window Website Opens in new window FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG Participation ended Germany EU contribution € 367 190,00 Address Schlossplatz 4 91054 Erlangen See on map Region Bayern Mittelfranken Erlangen, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Ulrich Winderl (Mr.) Links Contact the organisation Opens in new window Website Opens in new window ACADEMISCH ZIEKENHUIS LEIDEN Netherlands EU contribution € 489 600,00 Address Albinusdreef 2 2333 ZA Leiden See on map Region West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Activity type Higher or Secondary Education Establishments Administrative Contact Daan Katchaki (Dr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA Italy EU contribution € 485 604,00 Address Piazza dell'ateneo nuovo 1 20126 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Higher or Secondary Education Establishments Administrative Contact Anastasia Sguera (Dr.) Links Contact the organisation Opens in new window Website Opens in new window STICHTING RADBOUD UNIVERSITEIT Netherlands EU contribution € 1 132 080,00 Address Houtlaan 4 6525 XZ Nijmegen See on map Region Oost-Nederland Gelderland Arnhem/Nijmegen Activity type Higher or Secondary Education Establishments Administrative Contact Wim Bruinenberg (Mr.) Links Contact the organisation Opens in new window Website Opens in new window FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA Spain EU contribution € 263 620,00 Address Avenida de pio xii 55 31008 Pamplona See on map Region Noreste Comunidad Foral de Navarra Navarra Activity type Research Organisations Administrative Contact Andrew Solomon (Dr.) Links Contact the organisation Opens in new window Website Opens in new window INSTITUT CURIE France EU contribution € 469 600,00 Address Rue d ulm 26 75231 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Corrine Cumin (Ms.) Links Contact the organisation Opens in new window Website Opens in new window BIOSPACE LAB France EU contribution € 226 300,00 Address 11 rue de chenival 95690 Nesles-la-vallee See on map Region Ile-de-France Ile-de-France Val-d’Oise Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Pierre-Alix Dancer (Mr.) Links Contact the organisation Opens in new window MEDRES-MEDICAL RESEARCH GMBH Germany EU contribution € 215 500,00 Address Gleueler strasse 50 50931 Koln See on map Region Nordrhein-Westfalen Köln Köln, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Stefan Wecker (Mr.) Links Contact the organisation Opens in new window Website Opens in new window CAGE CHEMICALS SRL Italy EU contribution € 207 400,00 Address Via bovio 6 28100 Novara See on map Region Nord-Ovest Piemonte Novara Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Camilla Cavallotti (Dr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSIDAD DE NAVARRA Spain EU contribution € 220 000,00 Address Campus universitario edificio central 31080 Pamplona See on map Region Noreste Comunidad Foral de Navarra Navarra Activity type Higher or Secondary Education Establishments Administrative Contact Cristina Patsouris (Dr.) Links Contact the organisation Opens in new window Website Opens in new window THE HEBREW UNIVERSITY OF JERUSALEM Israel EU contribution € 158 400,00 Address Edmond j safra campus givat ram 91904 Jerusalem See on map Activity type Higher or Secondary Education Establishments Administrative Contact Jane Turner (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Westfälische Wilhelms-Universität Münster Germany EU contribution € 169 861,00 Address Schlossplatz 2 48149 Muenster See on map Region Nordrhein-Westfalen Münster Münster, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Katharina Steinberg (Dr.) Links Contact the organisation Opens in new window Website Opens in new window KATHOLIEKE UNIVERSITEIT LEUVEN Belgium EU contribution € 153 100,00 Address Oude markt 13 3000 Leuven See on map Region Vlaams Gewest Prov. 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