EUROPEAN DRUG INITIATIVE ON CHANNELS AND TRANSPORTERS

Project Information

EDICT

Grant agreement ID: 201924

Project closed

Start date 1 February 2008

End date 30 June 2012

Funded under

• Specific Programme "Cooperation": Health

Total cost € 15 718 166,68

EU contribution € 11 896 557,00

Coordinated by

UNIVERSITY OF LEEDS
United Kingdom

Objective

The European Drug Initiative on Channels and Transporters, EDICT, allies for the first time, partners with world-class expertise in both the structural and functional characterisation of membrane channels and transporters. State-of-the-art facilities and personnel for X-ray crystallography, Electron Microscopy and Nuclear Magnetic Resonance and the latest throughput technology, will provide infrastructure for scientists characterising channel and transport functions in man and pathogenic microorganisms. Our experts in the analyses of all the databases of these membrane proteins and molecular modelling will work with our industrial partners on specific targets chosen for their potential to improve the health of European citizens, increase the competitiveness of European health-related industries and businesses and address global health issues. EDICT will increase knowledge of biological processes and mechanisms involved in normal health and in specific disease situations, and transpose this knowledge into clinical applications. By combining computational and experimental analyses, existing detailed molecular models of channel and transporter proteins, and novel structures derived by our partners, will be analysed to identify the critical regions constituting drug targets. These basic discoveries will be translated via in silico and experimental strategies with our industrial partners into the design of novel drugs that modify activities of the membrane proteins for the benefit of the patients. The range of human proteins covered includes potassium channels, anion and cation transporters, neurotransmitter transporters, cation-transporting ATPases and mitochondrial transporters. Structures of bacterial homologues to the human proteins are exploited to inform the studies of their human counterparts

Fields of science

• natural sciences › chemical sciences › inorganic chemistry › alkali metals
• natural sciences › earth and related environmental sciences › geology › mineralogy › crystallography
• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• natural sciences › physical sciences › optics › microscopy › electron microscopy
• natural sciences › biological sciences › microbiology

Keywords

• Drug Design
• Ion Channels
• Membrane Related Diseases
• Membrane Transport Proteins
• Protein
• Protein Structure
• Structure-Function of Membrane Proteins

Programme(s)

• FP7-HEALTH - Specific Programme "Cooperation": Health

Topic(s)

• HEALTH-2007-2.1.1-5 - Structure-function analysis of membrane-transporters and channels for the identification of potential drug target sites

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

UNIVERSITY OF LEEDS

• EU contribution: € 1 890 220,87
• Address: WOODHOUSE LANE ; LS2 9JT Leeds ; United Kingdom
• Region: Yorkshire and the Humber › West Yorkshire › Leeds
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Kathy Brownridge (Ms.)
• Total cost: No data

Participants (27)

UNIVERSITE DE LAUSANNE

Switzerland

• EU contribution: € 244 228,00
• Address: QUARTIER UNIL CENTRE - BATIMENT UNICENTRE ; 1015 LAUSANNE
• Region: Schweiz/Suisse/Svizzera › Région lémanique › Vaud
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Alexandra Degago (Ms.)
• Total cost: No data

GOETEBORGS UNIVERSITET

Sweden

• EU contribution: € 319 534,00
• Address: VASAPARKEN ; 405 30 Goeteborg
• Region: Södra Sverige › Västsverige › Västra Götalands län
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Margareta Ahlqwist (Dr.)
• Total cost: No data

ASTON UNIVERSITY

United Kingdom

• EU contribution: € 308 551,00
• Address: ASTON TRIANGLE ; B4 7ET Birmingham
• Region: West Midlands (England) › West Midlands › Birmingham
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Eric Bourguignon (Mr.)
• Total cost: No data

UNIVERSITAT BASEL

Switzerland

• EU contribution: € 282 600,00
• Address: PETERSPLATZ 1 ; 4051 Basel
• Region: Schweiz/Suisse/Svizzera › Nordwestschweiz › Basel-Stadt
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Urs Mueller (Dr.)
• Total cost: No data

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Germany

• EU contribution: € 836 100,00
• Address: HOFGARTENSTRASSE 8 ; 80539 Munchen
• Region: Bayern › Oberbayern › München, Kreisfreie Stadt
• Activity type: Research Organisations
• Administrative Contact: Joachim Bormann (Dr.)
• Total cost: No data

FORSCHUNGSVERBUND BERLIN EV

Germany

• EU contribution: € 179 325,00
• Address: RUDOWER CHAUSSEE 17 ; 12489 Berlin
• Region: Berlin › Berlin › Berlin
• Activity type: Research Organisations
• Administrative Contact: Anne Hoener (Dr.)
• Total cost: No data

JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN

Germany

• EU contribution: € 607 128,00
• Address: THEODOR W ADORNO PLATZ 1 ; 60323 Frankfurt Am Main
• Region: Hessen › Darmstadt › Frankfurt am Main, Kreisfreie Stadt
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Christoph Denecke (Mr.)
• Total cost: No data

UNIVERSITAT ZURICH

Switzerland

• EU contribution: € 346 256,40
• Address: RAMISTRASSE 71 ; 8006 Zurich
• Region: Schweiz/Suisse/Svizzera › Zürich › Zürich
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Raimund Dutzler (Ms.)
• Total cost: No data

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH

Switzerland

• EU contribution: € 289 442,00
• Address: Raemistrasse 101 ; 8092 Zuerich
• Region: Schweiz/Suisse/Svizzera › Zürich › Zürich
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Johanna Blatter (Ms.)
• Total cost: No data

HEINRICH-HEINE-UNIVERSITAET DUESSELDORF

Germany

• EU contribution: € 229 200,00
• Address: UNIVERSITAETSSTRASSE 1 ; 40225 Dusseldorf
• Region: Nordrhein-Westfalen › Düsseldorf › Düsseldorf, Kreisfreie Stadt
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Uwe Droste (Mr.)
• Total cost: No data

RIJKSUNIVERSITEIT GRONINGEN

Netherlands

• EU contribution: € 351 789,00
• Address: Broerstraat 5 ; 9712CP Groningen
• Region: Noord-Nederland › Groningen › Overig Groningen
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Jan Poutsma (Dr.)
• Total cost: No data

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

France

• EU contribution: € 311 302,50
• Address: RUE LEBLANC 25 ; 75015 PARIS 15
• Region: Ile-de-France › Ile-de-France › Paris
• Activity type: Research Organisations
• Administrative Contact: Jacques Saudraix (Mr.)
• Total cost: No data

MEDICAL RESEARCH COUNCIL

United Kingdom

• EU contribution: € 1 389 510,75
• Address: 20 Park Crescent ; W1B 1AL LONDON
• Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
• Administrative Contact: Irina James (Ms.)
• Total cost: No data

AARHUS UNIVERSITET

Denmark

• EU contribution: € 335 516,25
• Address: NORDRE RINGGADE 1 ; 8000 Aarhus C
• Region: Danmark › Midtjylland › Østjylland
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Helle Alstrup (Ms.)
• Total cost: No data

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

United Kingdom

• EU contribution: € 583 073,00
• Address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD ; SW7 2AZ LONDON
• Region: London › Inner London — West › Westminster
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Brooke Alasya (Ms.)
• Total cost: No data

ASTRAZENECA AB

Sweden

• EU contribution: € 209 010,00
• Address: Vastra Maelarhamnen ; 151 85 Sodertaelje
• Region: Östra Sverige › Stockholm › Stockholms län
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Kay Callaghan (Dr.)
• Total cost: No data

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

• EU contribution: € 650 480,25
• Address: WELLINGTON SQUARE UNIVERSITY OFFICES ; OX1 2JD Oxford
• Region: South East (England) › Berkshire, Buckinghamshire and Oxfordshire › Oxfordshire
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Michael John Wilkinson (Mr.)
• Total cost: No data

STOCKHOLMS UNIVERSITET

Sweden

• EU contribution: € 516 720,00
• Address: UNIVERSITETSVAGEN 10 ; 10691 Stockholm
• Region: Östra Sverige › Stockholm › Stockholms län
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Ann Nielsen (Ms.)
• Total cost: No data

M V LOMONOSOV MOSCOW STATE UNIVERSITY

Russia

• EU contribution: € 106 800,00
• Address: LENINSKIE GORY MAIN BUILDING ; 119992 MOSCOW
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Alexander Rubtsov (Dr.)
• Total cost: No data

THE HEBREW UNIVERSITY OF JERUSALEM

Israel

• EU contribution: € 369 328,00
• Address: EDMOND J SAFRA CAMPUS GIVAT RAM ; 91904 Jerusalem
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Eran Vardi (Dr.)
• Total cost: No data

UNIVERSITA DEGLI STUDI DI MILANO

Italy

• EU contribution: € 142 800,00
• Address: Via Festa Del Perdono 7 ; 20122 Milano
• Region: Nord-Ovest › Lombardia › Milano
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Mario Ferrante (Mr.)
• Total cost: No data

FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)

Spain

• EU contribution: € 185 904,00
• Address: CARRER BALDIRI REIXAC 10-12 PARC SCIENTIFIC DE BARCELONA ; 08028 Barcelona
• Region: Este › Cataluña › Barcelona
• Activity type: Research Organisations
• Administrative Contact: Margarida Corominas (Ms.)
• Total cost: No data

HELSINGIN YLIOPISTO

Finland

• EU contribution: € 302 160,00
• Address: YLIOPISTONKATU 3 ; 00014 Helsingin Yliopisto
• Region: Manner-Suomi › Helsinki-Uusimaa › Helsinki-Uusimaa
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Sanna-Maija Miettinen (Dr.)
• Total cost: No data

KAROLINSKA INSTITUTET

Sweden

• EU contribution: € 229 900,00
• Address: Nobels Vag 5 ; 17177 Stockholm
• Region: Östra Sverige › Stockholm › Stockholms län
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Jill Blomstrand (Ms.)
• Total cost: No data

KOBENHAVNS UNIVERSITET

Denmark

• EU contribution: € 264 960,00
• Address: NORREGADE 10 ; 1165 Kobenhavn
• Region: Danmark › Hovedstaden › Byen København
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Ivan Kristoffersen (Mr.)
• Total cost: No data

XENTION LTD

United Kingdom

• EU contribution: € 209 268,00
• Address: Iconix Park, London Road, Pampisford ; CB22 3EG CAMBRIDGE
• Region: East of England › East Anglia › Cambridgeshire CC
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: David Madge (Dr.)
• Total cost: No data

UNIVERSITAETSKLINIKUM FREIBURG

Germany

• EU contribution: € 205 449,98
• Address: HUGSTETTER STRASSE 49 ; 79106 Freiburg
• Region: Baden-Württemberg › Freiburg › Freiburg im Breisgau, Stadtkreis
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Jürgen Dreyer (Mr.)
• Total cost: No data