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Breathing chlorinated compounds: unravelling the biochemistry underpinning (de)halorespiration, an exciting bacterial metabolism with significant bioremediation potential


Heterologous expression, purification and cofactor reconstitution of the reductive dehalogenase PceA from Dehalobacter restrictus.

Auteurs: Stephen E. J. Rigby; Karl Fisher; Hanno Sjuts; Mark S. Dunstan; David Leys
Identifiant permanent: Digital Object Identifier:10.1016/j.pep.2012.08.007

The transcriptional regulator CprK detects chlorination by combining direct and indirect readout mechanisms.

Auteurs: Kemp, Laura R.; Dunstan, Mark S.; Fisher, Karl; Warwicker, Jim; Leys, David
Identifiant permanent: PubMed Central ID:PMC3638464; PubMed ID:23479753; Digital Object Identifier:10.1098/rstb.2012.0323

Structure of the cobalamin-binding protein of a putative O-demethylase from Desulfitobacterium hafniense DCB-2

Auteurs: Sjuts, Hanno; Dunstan, Mark S.; Fisher, Karl; Leys, David
Identifiant permanent: Digital Object Identifier:10.1107/s0907444913011323; PubMed Central ID:PMC3727330; PubMed ID:23897483

Reductive dehalogenase structure suggests a mechanism for B12-dependent dehalogenation

Auteurs: Payne, Karl A. P.; Quezada, Carolina P.; Fisher, Karl; Dunstan, Mark S.; Collins, Fraser A.; Sjuts, Hanno; Levy, Colin; Hay, Sam; Rigby, Stephen E. J.; Leys, David
Identifiant permanent: PubMed Central ID:PMC4968649; PubMed ID:25327251; Digital Object Identifier:10.1038/nature13901

Epoxyqueuosine Reductase Structure Suggests a Mechanism for Cobalamin-dependent tRNA Modification.

Auteurs: Hanno Sjuts; Linus O. Johannissen; Mark S. Dunstan; David Leys; Karl Fisher; Sam Hay; Karl A. P. Payne; Bruno Bellina; Perdita E. Barran; Stephen E. J. Rigby
Publié dans: American Society for Biochemistry and Molecular Biology 2015
Identifiant permanent: PubMed Central ID:PMC4646009; PubMed ID:26378237; Digital Object Identifier:10.1074/jbc.m115.685693