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The role of RNA silencing in immunity and development in eukaryotes

Objective

RNA silencing is a pan-eukaryotic gene regulation process that involves RNA molecules 19-30nt in length. These molecules are produced by RNAse-III proteins in the Dicer family and engage into sequence-specific regulation of complementary DNA or RNA upon their incorporation into effector complexes. RNA silencing serves essential roles in biology but the molecular bases of its mechanisms are still poorly understood. One major aspect of the proposed project is to decipher genetically the composition of RNA silencing effector complexes and to understand how those complexes orchestrate the regulation of fundamental processes involved in cell differentiation, notably the process of dosage compensation during chromosome X inactivation in mammals. The second aspect is part of our ongoing efforts to understand the implication of small RNAs in plant and animal innate immunity, their impact on pathogen’s fitness and evolution, and how pathogens counteract small RNA-directed immune pathways.

Field of science

  • /natural sciences/biological sciences/genetics and heredity/chromosome
  • /natural sciences/biological sciences/zoology/mammalogy
  • /natural sciences/biological sciences/genetics and heredity/rna
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins

Call for proposal

ERC-2007-StG
See other projects for this call

Funding Scheme

ERC-SG - ERC Starting Grant

Host institution

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Address
Raemistrasse 101
8092 Zuerich
Switzerland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 375 670
Principal investigator
Olivier Voinnet (Dr.)
Administrative Contact
Olivier Voinnet (Prof.)

Beneficiaries (2)

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
EU contribution
€ 375 670
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments
Principal investigator
Olivier Voinnet (Dr.)
Administrative Contact
Olivier Voinnet (Prof.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

Participation ended

France
EU contribution
€ 524 330
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Administrative Contact
Denis Fix (Mr.)