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Content archived on 2024-06-18

Macrophage Systems Biology Applied To Disease Control

Objective

Cattle-farming is one of the most important agricultural activities in the EU. This project will address issues of the health and welfare of cattle and the safety of cattle products, focussing on diseases that are on the increase in European cattle population and are aware of growing concern elsewhere. Two related diseases will be targeted, bovine tuberculosis (TB) and bovine para-tuberculosis (Para-TB or Johnes disease). The objective of the project is to use a combined functional and classical genomics and system biology approaches (system genetics) to investigate host-pathogen interactions and the host immune response to mycobacterium infection. The outcome will be 1) increased knowledge of macrophage function the application of this knowledge will be to develop tests to identify infected animals, and 2) the identification of genes that regulate the response of an individual to infection: information that could be applied in selective breeding programmes. Specifically the project will use functional, comparative genomics and in silico analysis to understand the genetic control of variation in the outcomes of disease challenge to develop molecular diagnosis tools to improve disease surveillance and to assist in selective improvement of breeding of cattle to control these diseases. Hence the project will impact directly on improved animal health. Healthy livestock are more productive and so the improvements achieved will contribute to improved efficiency and profitability of animal production and competitiveness of animal production and hence the sustainability of farming systems. The work will contribute both to improved animal health and welfare and also to the improved safety of animal products and to safeguarding human health. The market requirements will be assessed in order to lead the development of project outcomes to commercially viable products to ensure that the research is appropriately and efficiently exploited.

Fields of science (EuroSciVoc)

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Keywords

Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)

Programme(s)

Multi-annual funding programmes that define the EU’s priorities for research and innovation.

Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

FP7-KBBE-2007-1
See other projects for this call

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

CP-FP - Small or medium-scale focused research project

Coordinator

"ISTITUTO SPERIMENTALE ITALIANO ""LAZZARO SPALLANZANI"""
EU contribution
€ 453 300,00
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

No data

Participants (8)

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