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Mechanisms of early protective exposures on allergy development

Objective

Allergy has developed into a major health concern in Europe. Allergic diseases can currently be managed effectively but not cured. The onset of allergies stars early in life and there is increasing evidence that exogenous factors affecting the incidence of these illnesses exert their effect early in life, in part even prenatally. The highly interdisciplinary EFRAIM project will prospectively investigate the main protective factors in early life influencing the development of allergies in birth cohorts conducted in allergy protective environments in five European countries. These birth cohorts have been enrolling over 1,000 children and have collected detailed information on the onset of allergic illnesses, objective measures of allergies and a vast amount of information about a number of environmental exposures. Large biobanks with a variety of biological samples have been established. In the EFRAIM project particular attention will be given to the potential role of dietary exposures, lifestyle and other environmental (e.g. microbial) exposures early in life which are causal determinants rather than triggers of the illness. The mechanisms mediating these protective exposures such as the maturation of immune responses, gut colonisation, the mucosal barrier function and the genetic and epigenetic factors interacting with the environmental exposures will be investigated. The knowledge about protective exposures early in life can be turned into the development of preventive strategies. The EFRAIM project will actively address two routes of preventive interventions in animal models and in vitro studies: the development of an allergy protective milk formula and the development of an allergy vaccine. Both approaches are based on knowledge gained in the human studies. The EFRAIM project is expected to produce ground-breaking new insights on protective agents and their mechanisms that can be used to prevent the further development of allergies.

Call for proposal

FP7-KBBE-2007-1
See other projects for this call

Coordinator

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Address
Geschwister Scholl Platz 1
80539 Muenchen
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 417 000
Administrative Contact
Erika Von Mutius (Prof.)

Participants (14)

KARDINAL SCHWARZENBERG'SCHES KRANKENHAUS BETRIEBSGESELLSCHAFT MBH
Austria
EU contribution
€ 147 000
Address
Kardinal Schwarzenbergstrasse 2-6
5620 Schwarzach
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Karl Obermaier (Mr.)
PHILIPPS UNIVERSITAET MARBURG
Germany
EU contribution
€ 307 000
Address
Biegenstrasse 10
35037 Marburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Harald Renz (Prof.)
University of Zurich
Switzerland
EU contribution
€ 167 000
Address
Ramistrasse 71
8006 Zurich
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Roger Lauener (Dr.)
UNIVERSITAET ULM
Germany
EU contribution
€ 207 000
Address
Helmholtzstrasse 16
89081 Ulm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Frank Gleixner (Mr.)
UNIVERSITE DE FRANCHE-COMTE
France
EU contribution
€ 167 000
Address
1 Rue Claude Goudimel
25000 Besancon
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Pauline Fournier (Ms.)
UNIVERSITAET BERN
Switzerland
EU contribution
€ 47 000
Address
Hochschulstrasse 6
3012 Bern
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Urs Frey (Prof.)
Protectimmun GmbH
Germany
EU contribution
€ 267 000
Address
Uckendorfer Strasse 237E
45886 Gelsenkirchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Marion Kauth (Dr.)
Agricultural Catchments Programme
Ireland
EU contribution
€ 187 000
Address
Oak Park
R93 Carlow
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mark Ryan (Mr.)
UNIVERSITAT BASEL
Switzerland
EU contribution
€ 147 000
Address
Petersplatz 1
4051 Basel
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Charlotte Braun-Fahrländer (Prof.)
TECHNISCHE UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 147 000
Address
Arcisstrasse 21
80333 Muenchen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ulrike Ronchetti (Ms.)
UNIVERSITEIT UTRECHT
Netherlands
EU contribution
€ 57 000
Address
Heidelberglaan 8
3584 CS Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Monique Hoek Van Der (Ms.)
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
EU contribution
€ 27 000
Address
Rue Leblanc 25
75015 Paris 15
Activity type
Research Organisations
Administrative Contact
Yves Le Ray (Mr.)
MEDIZINISCHE HOCHSCHULE HANNOVER
Germany
EU contribution
€ 30 000
Address
Carl-neuberg-strasse 1
30625 Hannover
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Michael Born (Mr.)
TERVEYDEN JA HYVINVOINNIN LAITOS
Finland
EU contribution
€ 667 000
Address
Mannerheimintie 166
00271 Helsinki
Activity type
Research Organisations
Administrative Contact
Unknown Unknown