Objective
Are genes randomly located around the genome? Recent studies suggest not. Other data also suggest that sex chromosomes contain an unusual assembly of genes. In this project we want to study genes whose expression is sex biased, but not necessarily sex specific. Many hormonal, anatomical and behavioural differences exist in males and females. One expects that these differences in sexes arise from the differences in gene expression. Are these differentially expressed genes more or less prevalent on sex chromosomes? And might the sex biased gene expression be related to differential susceptibility to disease of the two sexes? It is well known that some diseases are more common in females than males and vice versa. Understanding the sex-specific differences in gene expression might also then be of great help for both diagnosis and treatment of diseases.
There are only few large-scale analyses of the differential gene expression in male and female tissues and they are on organisms other than humans. There is great need for a comparative study of the gene expression in human males and females. We will approach this problem by analysing large amounts of human gene expression data, from normal as well as diseased tissues, which is collected in the numerous public databases. We will identify differentially expressed genes in the tissues from individuals of different sexes and analyse their distribution on different chromosomes. The sex dependent differential gene expression in normal and diseased tissue will be correlated with available disease statistics. This will be the first large scale comparative study of sex-dependent gene expression in human, which has application in genetics, physiology and medicine' s major research areas in Europe. The project will help in speeding up related research in third country by transfer of knowledge gained during the study. Thus this project, which links genomic research to health, will lead to long-term collaborations.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences databases
- medical and health sciences basic medicine physiology
- natural sciences biological sciences genetics chromosomes
- natural sciences biological sciences genetics genomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-7
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IIF - Marie Curie actions-Incoming International Fellowships
Coordinator
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.