Objective
In recent years functional genomics of eicosanoid synthesizing enzymes and molecular enzymology of these biocatalysts have become a hotspot in eicosanoid research. One reason for this switch in interest is the fact that rational drug development requires detailed knowledge on structural biology of enzymes and receptors to effectively prevent their interactions with the natural ligands.
The present research project is aimed at assembling a comprehensive picture of lipoxygenase/cyclooxygenase catalysis employing dynamic models. To understand the fundamental principles of the enzymatic reaction we will combine biochemical and molecular biological approaches and use them for investigation of elementary steps of the reaction cascades with particular emphasis on the substrate binding and intra-enzyme oxygen movement.
Structurally, the project can be divided into three subprojects:
i) substrate binding of mammalian LOX/COX-isoforms;
ii) investigations of solution structure of LOX/COX-isoforms; inter-domain movement in LOXs and its regulatory relevance;
iii) structural identification of oxygen access channel(s) applying an integrated research strategy that involves molecular modelling (structural modelling and molecular dynamics) and site-directed mutagenesis.
Eicosan oids and eicosanoid synthesizing enzymes have been implicated in the pathogenesis of atherosclerosis, inflammation, osteoporosis and cancer, which are of major health political relevance for all industrialized countries. Our results are expected to open new perspectives in regulation of catalytic activity of LOX/COX-isoforms providing an improved structural basis for the development of novel therapeutics.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- natural sciences chemical sciences organic chemistry
- natural sciences chemical sciences catalysis biocatalysis
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
- natural sciences biological sciences molecular biology structural biology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-7
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IIF - Marie Curie actions-Incoming International Fellowships
Coordinator
BERLIN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.