Skip to main content

CAse studies on the Development and Application of in-Silico Techniques for Environmental hazard and Risk assessment

Objective

Implementation of REACH requires demonstration of the safe manufacture and use of chemicals. REACH aims to achieve a proper balance between societal, economic and environmental objectives, and attempts to efficiently use the scarce and scattered information available on the majority of substances. Thereupon REACH aims to reduce animal testing by optimized use of in silico and in vitro information on related compounds. The REACH proposals advocate the use of non-animal testing methods, but guidance is needed on how these methods should be used. The procedures include alternative methods such as chemical and biological read-across, in vitro results, in vivo information on analogues, (Q)SARs, and exposure-based waiving. The concept of Intelligent Testing Strategies for regulatory endpoints has been outlined to facilitate the assessments. Intensive efforts are needed to translate the concept into a workable, consensually acceptable, and scientifically sound strategy. CADASTER aims at providing the practical guidance to integrated risk assessment by carrying out a full hazard and risk assessment for chemicals belonging to four compound classes. A DSS will be developed that will be updated on a regular basis in order to accommodate and integrate the alternative methods mentioned above. Operational procedures will be developed, tested, and disseminated that guide a transparent evaluation of four classes of emerging chemicals, explicitly taking account of variability and uncertainty in data and in models. The main goal is to exemplify the integration of information, models and strategies for carrying out safety-, hazard- and risk assessments for large numbers of substances. Real risk estimates will be delivered according to the basic philosophy of REACH of minimizing animal testing, costs, and time. CADASTER will show how to increase the use of non-testing information for regulatory decision whilst meeting the main challenge of quantifying and reducing uncertainty.

Field of science

  • /humanities/philosophy, ethics and religion/philosophy

Call for proposal

FP7-ENV-2007-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU
Address
Antonie Van Leeuwenhoeklaan 9
3721 MA Bilthoven
Netherlands
Activity type
Research Organisations
EU contribution
€ 550 201
Administrative Contact
Willie Peijnenburg (Prof.)

Participants (8)

ZAVOD ZA ZDRAVSTVENO VARSTVO MARIBOR
Slovenia
EU contribution
€ 333 768
Address
Prvomajska 1 1
2000 Maribor
Activity type
Research Organisations
Administrative Contact
Ales Gutmaher (Mr.)
UNIVERSITA DEGLI STUDI DELL'INSUBRIA
Italy
EU contribution
€ 285 750
Address
Via Ravasi 2
21100 Varese
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Adriana Jacona (Ms.)
IVL SVENSKA MILJOEINSTITUTET AB
Sweden
EU contribution
€ 308 150
Address
Po Box 21060
100 31 Stockholm
Activity type
Research Organisations
Administrative Contact
Magnus Rahmberg (Dr.)
LINNEUNIVERSITETET
Sweden
EU contribution
€ 366 150
Address
Linnaeus University
35195 Vaxjo
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Johanna Egerup (Ms.)
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
EU contribution
€ 362 375
Address
Ingolstadter Landstrasse 1
85764 Neuherberg
Activity type
Research Organisations
Administrative Contact
Jürgen Ertel (Dr.)
IDEACONSULT LIMITED LIABILITY COMPANY
Bulgaria
EU contribution
€ 127 040
Address
Angel Kanchev 4
1000 Sofia
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Luben Boyanov (Dr.)
STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
EU contribution
€ 321 100
Address
Geert Grooteplein Noord 9
6525 EZ Nijmegen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mark Huijbregts (Dr.)
MIKE COMBER CONSULTING SPRL
Belgium
EU contribution
€ 37 500
Address
Square Prevost Delaunay 123
1030 Bruxelles
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Mike Comber (Dr.)