Objective
Complete colonization of the gut by enteric neural precursors depends on activation of endothelin receptor B (EDNRB) by its ligand endothelin 3 (EDN3). Loss of EDN3/EDNRB signaling leads to aganglionosis of distal gut (Hirschsprung s disease, HSCR) caused by failure of neural crest stem cells (NCSCs) to migrate into the distal gut. We hypothesize that EDN3/EDNB-signalling is only involved in the migration of NCSC after embryonic day 12.5 during ENS development and is not necessary for proliferation, survival or differentiation of NCSCs in later stages. Thus, the migration defect caused by Ednrb deficiency could be bypassed by transplanting NCSCs directly into the aganglionic region of Ednrbsl/sl rats (spotting lethal rats that suffer of distal aganglionosis). We will analyze if transplanted NCSCs engraft and survive in the gut, undergo differentiation into functional enteric neurons and improve gut motor function. This study will provide evidence for stem cell replacement as a possible therapeutic tool.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences clinical medicine oncology skin cancer melanoma
- social sciences sociology social issues social inequalities
- medical and health sciences medical biotechnology cells technologies stem cells
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-6
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
OIF - Marie Curie actions-Outgoing International Fellowships
Coordinator
22085 VALENCIA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.