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Biofunctionalized Metal and Magnetic Nanoparticles for Targeted Tumor Therapy

Objective

The cause of diseases is often unknown, but their origin can frequently be found at the biomolecular and cellular level situated on nm-scale. Early diagnostics combined with early intervention on that nanoscale is one of the holy grail of modern medicine. Inorganic nanoparticles are very promising agents in that respect. One of the promising biomedical applications of these nanoparticles is their use as agents for tumor hyperthermia. Hyperthermia is a form of cancer treatment that uses an elevated temperature to kill the tumor tissue. Compared to the more conventional surgical procedures, it is hailed as a less invasive approach that could be used for small, non-defined tumors. Well-designed instrumentation in combination with engineered inorganic nanoparticles that (a) possess the desired physical properties to generate a local heat and that (b) can specifically target the tumor offer immense potentials for targeted hyperthermia therapy. The overall objective of the present multi-disciplinary project is to develop and to explore various metal/magnetic nanoparticles as agents for targeted tumor therapy. To strive for this overall objective, a successful integration and convergence of different technologies at the nanoscale is indispensable. In this project, we will focus on the synthesis routes of tailor designed biofunctionalized nanoparticles for hyperthermia. This requires a profound physical and chemical characterization of the synthesized nanostructures, but the project is certainly not limited hereto. It will also include a toxicological and biological evaluation of the different nanoparticles. Hereby a detailed exploration and characterization of the interaction mechanism of the biological entities and the nanostructures will be pursued to obtain a better understanding of the phenomena occurring at the nanoscale. In addition, this project also comprises the design of advanced instrumentation that can be used for a controlled hyperthermia treatment.

Call for proposal

FP7-NMP-2007-SMALL-1
See other projects for this call

Coordinator

INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM
Address
Kapeldreef 75
3001 Leuven
Belgium
Activity type
Research Organisations
EU contribution
€ 822 387
Administrative Contact
Christine Van Houtven (Ms.)

Participants (7)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 397 290
Address
Rue Michel Ange 3
75794 Paris
Activity type
Other
Administrative Contact
Hélène Le Roux (Ms.)
LEIBNIZ-INSTITUT FUER PHOTONISCHE TECHNOLOGIEN E.V.
Germany
EU contribution
€ 333 540
Address
Albert Einstein Strasse 9
07745 Jena
Activity type
Research Organisations
Administrative Contact
Frank Sondermann (Mr.)
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
EU contribution
€ 573 791
Address
Hansastrasse 27C
80686 Munchen
Activity type
Research Organisations
Administrative Contact
Maximilian Steiert (Mr.)
KARLSRUHER INSTITUT FUER TECHNOLOGIE
Germany
EU contribution
€ 658 342
Address
Kaiserstrasse 12
76131 Karlsruhe
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Natascha Wallburg (Ms.)
AARHUS UNIVERSITET
Denmark
EU contribution
€ 379 100
Address
Nordre Ringgade 1
8000 Aarhus C
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Karin Sutherland (Ms.)
PEPSCAN THERAPEUTICS BV
Netherlands
EU contribution
€ 365 000
Address
Zuidersluisweg 2
8243 RC Lelystad
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Nard Langendijk (Mr.)
IMEGO AB
Sweden
EU contribution
€ 196 900
Address
Arvid Hedvalls Backe 4
40014 Gothenburg
Activity type
Research Organisations
Administrative Contact
Krozer Anatol (Prof.)