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Comprehensive assessment of hazardous effects of engineered nanomaterials on the immune system

Objective

Engineered nanomaterials (ENs) present tremendous opportunities for industrial growth and development, and hold great promise for the enrichment of the lives of citizens, in medicine, electronics, and numerous other areas. However, there are considerable gaps in our knowledge concerning the potential hazardous effects of ENs on human health and the environment. Our EU-US partnership is committed to filling these knowledge gaps through a comprehensive assessment of ENs, with particular focus on effects on the immune system. The immune system is designed to respond to pathogens and foreign particles, and a core concept underpinning the current project is that the recognition versus non-recognition of ENs by immune-competent cells will determine the distribution as well as the toxicological potential of these materials. Our multidisciplinary consortium will focus on the procurement, synthesis and detailed physico-chemical characterization of representative categories of ENs, and the monitoring of potential hazardous effects using an array of in vitro and in vivo systems, as well as transcriptomic and oxidative lipidomic testing to determine specific nanotoxic profiles (signatures) of these materials. The final and integrative component of our research project is risk assessment of potential adverse effects of ENs on human health, and the dissemination of our findings. Through our comprehensive approach, which combines analytical procedures from many different disciplines and leading experts from several national institutes devoted to occupational and environmental safety, we aim to establish a panel of read-out systems for the prediction of the toxic potential of existing and emerging ENs, thus enabling a continuous and sustainable growth of the nanotechnologies. Overall, the results generated through this international program will contribute to the understanding and mitigation of possible adverse effects of nanomaterials.

Field of science

  • /engineering and technology/nanotechnology
  • /medical and health sciences/basic medicine/immunology
  • /natural sciences/physical sciences/theoretical physics/particles
  • /engineering and technology/nanotechnology/nano-materials

Call for proposal

FP7-NMP-2007-SMALL-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

KAROLINSKA INSTITUTET
Address
Nobels Vag 5
17177 Stockholm
Sweden
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 977 500
Administrative Contact
Per-Olof Larsson (Mr.)

Participants (9)

KUNGLIGA TEKNISKA HOEGSKOLAN
Sweden
EU contribution
€ 348 000
Address
Brinellvagen 8
100 44 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Alf Thomas Sjöland (Mr.)
UPPSALA UNIVERSITET
Sweden
EU contribution
€ 348 000
Address
Von Kraemers Alle 4
751 05 Uppsala
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eva Lind (Ms.)
UNIVERSITAET ZU KOELN
Germany
EU contribution
€ 348 000
Address
Albertus Magnus Platz
50931 Koeln
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Wilfried Hundt (Ms.)
TURUN YLIOPISTO
Finland
EU contribution
€ 554 500
Address
Yliopistonmaki
20014 Turku
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eliisa Särkilahti (Dr.)
EIDGENOSSISCHE MATERIALPRUFUNGS- UND FORSCHUNGSANSTALT
Switzerland
EU contribution
€ 482 500
Address
Ueberlandstrasse 129
8600 Dubendorf
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Heidi Leutwyler (Ms.)
INSTITUTE OF OCCUPATIONAL MEDICINE
United Kingdom
EU contribution
€ 300 000
Address
Research Avenue North, Riccarton 45
EH14 4AP Edinburgh
Activity type
Research Organisations
Administrative Contact
Susan Scarisbrick (Ms.)
UNIVERSITY OF PITTSBURGH
United States
Address
University Place 123
15213 Pittsburgh
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Matthew Weaver (Mr.)
NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH
United States
Address
Willowdale Road Ms L 2015
26505 Morgantown
Activity type
Research Organisations
Administrative Contact
Anna Shvedova (Dr.)
NORTH CAROLINA STATE UNIVERSITY
United States
Address
Sullivan Drive 270 Suite 240 Box 7514
27695 7514 Raleigh
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Matthew Ronning (Dr.)