Objective The demand for a next-generation of technologies for DNA sequencing that will provide fast and affordable DNA decoding is pressing. Present bio-chemical schemes are time consuming and expensive, thus cheap and fast alternatives for DNA “reading” are of great need. This is now internationally recognized. For example, the US NIH recently awarded 40M$ in grants overpiloting projects to spur development of these innovative technologies. The goal of this project is to investigate a novel single-molecule DNA se-quencing nanotechnology protocol (gene sequencer) that has potential to sequence a molecule of genomic dimensions in hours without expensive and fault sensitive DNA copying steps and chemical reactions. The gene sequencer is based on the electrical characterization of individual nucleo-bases, while DNA passes through a nanopore with integrated nanotube side-electrodes. The research proposed here will provide a unique combina-tion of state of the art capabilities for cutting and usage of single wall carbon nanotubes as electrodes forming a lithographically fabricated “nanogap” with single-nanometer precision. In addition, the synergy of consortium resources for electrical characterization and leading theoretical skills for nanotransport will provide new solutions and information for an answer on the proof-of-principle question: is it possible to detect different types of DNA bases by their electrical properties? The overall objective of our collaborative research is to develop cheap and high-speed DNA sequencing technology. This will be achieved trough the following steps: 1. Fabrication of single wall carbon nanotube junction-gate for molecular recognition; 2. Exploring the interaction and conduction mechanisms between DNA and nanotube-electrode and DNA-nanopore; 3. Electrical characterization of the DNA nucleobases; 4. Development of model nano-electronic device for single-base DNA electrical characterization and decoding. Fields of science natural sciencesbiological sciencesgeneticsDNAengineering and technologynanotechnologynano-materialsnatural scienceschemical sciences Keywords DNA-nanopore interaction DNA-nanotube interaction Electrical properties of nucleobases Next-generation DNA sequencing tech Rapid DNA Sequencing Programme(s) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Topic(s) NMP-2007-1.1-1 - Nano-scale mechanisms of bio/non-bio interactions Call for proposal FP7-NMP-2007-SMALL-1 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator INSTITUT ZA FIZIKU Address Pregrevica 118 11080 Beograd Serbia See on map Activity type Research Organisations Administrative Contact Zikic Radomir (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Switzerland EU contribution € 396 000,00 Address Batiment ce 3316 station 1 1015 Lausanne See on map Region Schweiz/Suisse/Svizzera Région lémanique Vaud Activity type Higher or Secondary Education Establishments Administrative Contact László Forró (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data THE HEBREW UNIVERSITY OF JERUSALEM Israel EU contribution € 360 200,00 Address Edmond j safra campus givat ram 91904 Jerusalem See on map Activity type Higher or Secondary Education Establishments Administrative Contact Eran Vardi (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN Ireland EU contribution € 339 725,00 Address College green trinity college D02 CX56 Dublin 2 See on map Region Ireland Eastern and Midland Dublin Activity type Higher or Secondary Education Establishments Administrative Contact Deirdre Savage (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITAET REGENSBURG Germany EU contribution € 486 008,00 Address Universitatsstrasse 31 93053 Regensburg See on map Region Bayern Oberpfalz Regensburg, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Christian Blomeyer (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data NUWAVE SYSTEM LTD United Kingdom EU contribution € 61 400,00 Address Percy street 5 office 4 W1T 1DG London See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Cvitanovic Nikola (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data KARLSRUHER INSTITUT FUER TECHNOLOGIE Germany EU contribution € 106 992,00 Address Kaiserstrasse 12 76131 Karlsruhe See on map Region Baden-Württemberg Karlsruhe Karlsruhe, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Claudia Sommer (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
