Objective
Biology is moving from describing phenomena to understanding the design principles and dynamic operation of cellular modules, entire cells, and even organisms. This new approach, which has been termed systems biology, aims to holistically understand biological processes by employing mathematical analysis and computational tools to integrate the information content obtained in experimental biology and engineering.
In this project, experimental and theoretical studies will be integrated to achieve a better understanding of the dynamic operation of glucose repression signalling pathways in yeast for design of glucose de-repressed strains. Such strains are industrially attractive as cell factories for improving baker's yeast production from molasses, bioethanol production for sugar mixtures, and heterologous protein therapeutic production. Moreover, since glucose repression in yeast serves as a model for nutrient sensing in eukaryotic cells, the development of algorithms for this system may be applied to mapping of signa transduction pathways in higher eukaryotes - including humans.
This will ultimately facilitate drug discovery and drug target identification for complex diseases. To achieve this goal, genome-scale models will be combined with DNA array and metabolite profiling data of several glucose repression mutants. Detailed characterization of these mutants by model guided analysis of global cellular function will allow mapping of all pleotrophic effects, identification of co-regulated metabolic patterns, and subsequent engineering of the desired strains. This study will have a broad impact on the field of systems biology and yeast physiology/genetics.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- natural sciences biological sciences genetics DNA
- natural sciences mathematics pure mathematics mathematical analysis
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine physiology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-7
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IIF - Marie Curie actions-Incoming International Fellowships
Coordinator
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.