Objective
X-ray crystallography (XR) provides atomic resolution models of subunits of large biological assemblies, while electron microscopy (EM) allows lower-resolution imaging of whole macromolecular complexes. Combining the information from both techniques by fitting an atomic XR model into an EM density map enables in principle atomic-level interpretation of the EM data. We propose first to develop graphical software for manually fitting atomic XR models into EM data while simultaneously calculating the correlation between the models and the data using a fast reciprocal-space method [Navaza et al., Acta Crys. D58 (2002), 1820].
Second, we plan to implement an automatic fitting procedure with a complete 6-dimensional (3 rotations and 3 translations) search, based on a recently developed 6D extension of the fast rotational matching technique [Kovacs et al., Acta Crys. D59 (2003), 1371]. As a complement to these methodological developments, we will study using EM the structure of SIRV1, a rudivirus infecting thermophilic Archaea [Prangishvili et al., Genetics 152 (1999), 1387]. We will then use our newly developed software to fit the structures of viral proteins into the EM reconstruction.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences software
- natural sciences biological sciences microbiology virology
- natural sciences earth and related environmental sciences geology mineralogy crystallography
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences physical sciences optics microscopy electron microscopy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-12
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.