Objective
Apoptosis is a genetic program that kills cells that proliferate too much or in the wrong place in the body. Transplanted stem cells hold great promise for the treatment of degenerative diseases. There are several reasons why understanding stem cell apoptosis will further the therapeutic use of stem cells. First, stem cells must be cultured in sufficient numbers for treatment. Second, to repair a tissue, a stem cell must survive and persist in the damaged tissue. Identifying ways to promote stem cell survival by blocking apoptosis will serve both these goals. Finally, there is a growing understanding that aberrant proliferation in stem cells can cause cancer. Specifically inducing apoptosis in transplanted stem cells would be a powerful strategy in limiting this cancer risk. The research proposed here investigates the role of key apoptotic genes in controlling stem cell behaviour. This work will serve as a strong and necessary foundation for achieving the longer term goal of facilitating stem cell therapy. Specifically, the proposed experiments investigate how stem cells regulate caspases, proteases that are key components of the apoptotic machinery. Preliminary data reveal that different viable mouse embryonic, adult rat mesenchymal and haematopoietic stem cells have higher caspase-like activity than viable non-stem cells. The long term goal is to determine the role of this activity in stem cell potency. The specific experiments described here will identify the protease responsible for the activity in mouse embryonic stem cells using a combination of biochemical and genetic approaches. There is controversy, both scientific and ethical over the therapeutic use of embryonic stem cells. Therefore, adult human mesenchymal stem cells will also be tested for the activ ity as this cell type has more therapeutic relevance.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences cell biology
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences clinical medicine oncology
- medical and health sciences clinical medicine transplantation
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-12
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IRG - Marie Curie actions-International re-integration grants
Coordinator
GALWAY
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.