Objective
In eukaryotes the avaliability of the genetic information stored in the DNA is modulated by the interactions of this molecule with a broad spectrum of nuclear proteins such as histones and non-histone proteins. Histones are the main protein components of t he chromatin, where core histones organize DNA into nucleosome core particles and the linker histones bind to the regions contacting adjacent nucleosomes in the chromatin fiber. Although there has recently been a renewed interest in the functional and stru ctural characterization of histone variants, their role in the modulation of chromatin folding and dynamics is poorly understood. Histones H2A and H1 are characteristic for presenting the widest variability of variants among histones, including roles relat ed to DNA double-strand breaks repair, cell cycle checkpoints, and tumor supression. The present project represents a very innovative, high quality and multidisciplinary scientific work whose aim is to develop a molecular and evolutionary analysis of diffe rent core and linker histone proteins. The objetives proposed are: 1) the isolation and characterization of core and linker histone variants in vertebrate and protozoan lineages, 2) the molecular evolutionary analysis of core and linker histone variants to wards their functional diversification related to different chromatin structures, 3) the structural and functional characterization of chromatin complexes reconstituted from core histone variants including H2A.X and H2A.Z and further characterization of th e interactions of linker histones with chromatin. The analysis of such protein structures and the functional consequences of their modes of interaction with DNA will allow us to establish links with mechanisms involved in the altered chromatin conformation s arising from pathological states as cancer.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology materials engineering fibers
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine oncology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-6
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
OIF - Marie Curie actions-Outgoing International Fellowships
Coordinator
A CORUÑA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.