Objective Consumption of addictive drugs causes changes in the brain areas involved in rewarding behaviours that are essential to an animal's survival and adaptation. One of these areas is the nucleus accumbens. Normally occurring synaptic plasticity in the nucleus accumbens; such as a long-term decrease in synaptic strength mediated by cannabinoids (long-term depression); can change after brief or chronic exposure to addictive drugs.My project will examine commonalities between changes in long-term depression in the nucleus accumbens induced by in vivo administration of major classes of addictive drugs. I will then look for these changes in an animal model of addiction, where the animals display drug seeking behaviours similar to people suffering from withdrawal. Keywords addiction cannabinoid long-term depression Programme(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Topic(s) MOBILITY-2.3 - Marie Curie Incoming International Fellowships (IIF) Call for proposal FP6-2004-MOBILITY-7 See other projects for this call Funding Scheme IIF - Marie Curie actions-Incoming International Fellowships Coordinator EQUIPE AVENIR INSERM INSTITUT MAGENDIE Address 146 rue léo saignat Bordeaux France See on map Links Website Opens in new window EU contribution No data
