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Molecular mechanism of separase dependent PP2ACdc55 downregulation

Objective

Activation of the protease separase at anaphase onset leads to cleavage of cohesin, thereby triggering chromosome segragation. At the same time, an essential protease-independent function of separase promotes cell cycle progression out of mitosis. In the host laboratory it has been recently shown that separase interacts with the Cdc55 isoform of protein phosphatase 2A (PP2ACdc55) at anaphase onset, downregulating it (Queralt et al. 2006). However, the molecular nature of this non-proteolytic activity of separase and how it mediates PP2ACdc55 downregulation is still unknown. In this research project we propose to address the molecular mechanism by which separase downregulates PP2ACdc55 at anaphase onset.

Call for proposal

FP7-PEOPLE-2007-2-1-IEF
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Funding Scheme

MC-IEF - Intra-European Fellowships (IEF)

Coordinator

CANCER RESEARCH UK LBG
Address
St John Street 407 Angel Building
EC1V 4AD London
United Kingdom
Activity type
Research Organisations
EU contribution
€ 169 390,93
Administrative Contact
Louisa Jacobs (Ms.)