Objective Cell separation is a critical process for plants. Germinating seedlings emerge from their seed coats, anthers dehisce, fruit ripen, and organs are shed as a result of plant cell separation. To date, several cell wall remodeling enzymes associated with cell separation have been identified, however very little is known about the signals and mechanisms controlling their expression. The host laboratory has recently made major advances in the identification of the signals and molecular mechanisms regulating cell separation during lateral root emergence. The auxin influx transporter LAX3 allows the auxin inducible expression of a set of cell wall remodeling genes in front of the lateral root primordium to promote cell separation. The expression of these genes is dependant on the AUX/IAA proteins SLR1 and SHY2. The main aim of the present project is to study the signals and regulatory network that coordinates plant cell separation employing lateral root emergence as a model. I propose to adopt a Multidisciplinary Integrative Biology based approach which takes advantage of the facilities and expertise available in the host laboratory. Functional genomic, chemical genetic and mathematical modeling approaches will allow to identify new regulatory components and target genes then to build a regulatory network that will be modeled and tested. Fields of science agricultural sciencesagriculture, forestry, and fisheriesagriculturehorticulturefruit growingnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymesnatural sciencesmathematicsapplied mathematicsmathematical model Keywords Auxin influx Cell separation LAX3 Lateral root emergence Plant development Regulatory network Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) PEOPLE-2007-2-1.IEF - Marie Curie Action: "Intra-European Fellowships for Career Development" Call for proposal FP7-PEOPLE-2007-2-1-IEF See other projects for this call Funding Scheme MC-IEF - Intra-European Fellowships (IEF) Coordinator THE UNIVERSITY OF NOTTINGHAM Address University park NG7 2RD Nottingham United Kingdom See on map Region East Midlands (England) Derbyshire and Nottinghamshire Nottingham Activity type Higher or Secondary Education Establishments Administrative Contact Malcolm Bennett (Prof.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 178 307,05
